Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability.

Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability. Research Abstract Details 

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Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability. Abstract Text:

A Falini,G Calabrese,M Filippi,D Origgi,S Lipari,B Colombo,G Comi,G Scotti,

PURPOSE: We determined the clinical utility of proton MR spectroscopy in defining the extent of disability in benign versus secondary-progressive multiple sclerosis (MS). METHODS: Thirty patients with clinically definite MS, including 16 patients with benign MS and 14 with secondary-progressive MS, and a group of 13 healthy volunteers were studied with combined stimulated-echo acquisition mode proton MR spectroscopy and MR imaging (all patients received contrast material). RESULTS: Acute enhancing lesions of benign and secondary-progressive MS were characterized by a reduction in N-acetylaspartate (NAA)/choline and NAA/creatine and an increase in inositol compounds/creatine as compared with normal white matter. Such variations were also detected in chronic unenhancing lesions in patients with secondary-progressive MS, although they were not found in chronic unenhancing lesions in patients with benign MS. Chronic lesions of the two forms of the disease have significative differences in NAA and inositol signals. CONCLUSION: Proton MR spectroscopy is able to show metabolic changes occurring in the white matter of patients with MS. Such changes differ according to the phase (acute versus chronic) and the clinical form (benign versus secondary-progressive) of the disease.

Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability. Publishing Authors By Initials

A Falini,G Calabrese,M Filippi,D Origgi,S Lipari,B Colombo,G Comi,G Scotti,

For similar diagnosis: diagnostic techniques and procedures: diagnostic techniques, neurological: neurologic examination research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic techniques, neurological: neurologic examination research

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Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJNR. American journal of neuroradiology

VOLUME: 19

Page Numbers: 223-9

Journal Abbreviation:

ISSN: 0195-6108

DAY: 14

MONTH: Feb

YEAR: 1998

Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability. Information

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LANGUAGE: eng

NlmUniqueID: 8003708

Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability. Keywords Mesh Terms:

KEYWORDS: Neurologic Examination

MESH TERMS: diagnosis

Chemical & Substance for Abstract: Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability. Information

Substance Name: N-acetylaspartate

Registry Number: 997-55-7

Grant and Affiliation Information for Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability.

AFFILIATION: Department of Neuroradiology, Scientific Institute San Raffaele Hospital, University of Milan, Italy.

Country: UNITED STATES

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MEDLINETA: AJNR Am J Neuroradiol

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