Beneficial effects of the dual L- and T-type ca(2+) channel blocker efonidipine on cardiomyopathic hamsters.

Beneficial effects of the dual L- and T-type ca(2+) channel blocker efonidipine on cardiomyopathic hamsters. Research Abstract Details 

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Beneficial effects of the dual L- and T-type ca(2+) channel blocker efonidipine on cardiomyopathic hamsters. Abstract Text:

Shinsuke Suzuki,Tomoko Ohkusa,Katsushige Ono,Takashi Sato,Masa-Aki Yoshida,Masafumi Yano,Satoshi Takebayashi,Masunori Matsuzaki,Shinsuke Suzuki,Tomoko Ohkusa,Katsushige Ono,Takashi Sato,Masa-aki Yoshida,Masafumi Yano,Satoshi Takebayashi,Masunori Matsuzaki,Shinsuke Suzuki,Tomoko Ohkusa,Katsushige Ono,Takashi Sato,Masa-aki Yoshida,Masafumi Yano,Satoshi Takebayashi,Masunori Matsuzaki,

Background The T-type Ca(2+) channel (TCC) is activated, and abnormalities of the TCC may be related to the pathogenesis of Ca(2+) overload, in cardiomyopathic hamster hearts. The aims of the present study were to investigate the alteration in expression of the TCC and to examine the effects of a dual L-and T-type Ca(2+) channel blocker, efonidipine (EFO), on cardiac function and TCC during development of heart failure in UM-X7.1 cardiomyopathic hamsters. Methods and Results UM-X7.1 and golden hamsters were examined, and EFO was administered at the age of 20 weeks for 4 weeks. Cardiac function was examined, the expression of TCCalpha1G was measured, and ventricular myocytes were subjected to a patch-clamp study. At 24 weeks, vehicle-treated UM-X7.1 hamsters exhibited significant increases in left ventricular (LV) size, with marked decreases in ejection fraction (LVEF) compared with golden hamsters. In the UM-X7.1 group, the expression of TCCalpha1G increased during development of heart failure compared with the golden hamster group. In the UM-X7.1 group, EFO treatment significantly attenuated the decrease of LVEF without affecting blood pressure compared with the vehicle group. EFO treatment decreased heart rate (by~10%) in both groups. In the golden hamster group, EFO treatment did not affect LV function. The TCC current in ventricular myocytes was significantly increased in UM-X7.1, and was inhibited by EFO in a dose-dependent manner. Conclusions In cardiomyopathic hamster hearts, abnormalities in the TCC may be at least in part related to the pathogenesis of abnormal Ca(2+) homeostasis, and TCC-blocker treatment may decrease the TCC current, resulting in an improvement of cardiac function. TCC blocker therapy might be a new strategy for certain types of heart failure. (Circ J 2007; 71: 1970 - 1976).

Beneficial effects of the dual L- and T-type ca(2+) channel blocker efonidipine on cardiomyopathic hamsters. Publishing Authors By Initials

S Suzuki,T Ohkusa,K Ono,T Sato,MA Yoshida,M Yano,S Takebayashi,M Matsuzaki,S Suzuki,T Ohkusa,K Ono,T Sato,MA Yoshida,M Yano,S Takebayashi,M Matsuzaki,S Suzuki,T Ohkusa,K Ono,T Sato,MA Yoshida,M Yano,S Takebayashi,M Matsuzaki,

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Beneficial effects of the dual L- and T-type ca(2+) channel blocker efonidipine on cardiomyopathic hamsters. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Circulation journal : official journal of the Japa

VOLUME: 71

Page Numbers: 1970-6

Journal Abbreviation: Circ. J.

ISSN: 1346-9843

DAY: 26

MONTH: Dec

YEAR: 2007

Beneficial effects of the dual L- and T-type ca(2+) channel blocker efonidipine on cardiomyopathic hamsters. Information

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LANGUAGE: eng

NlmUniqueID: 101137683

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AFFILIATION: Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine.

Country: Japan

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MEDLINETA: Circ J

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