Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid.

Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid. Abstract Text:

Tsukasa Kirimoto,Koushi Nakano,Kenji Irimura,Yukio Hayashi,Naosuke Matsuura,Mamoru Kiniwa,Toshinori Oka,Naoki Yoshimura,

OBJECTIVE: To examine the effects of suplatast tosilate (IPD-1151T), a Th2 cytokine inhibitor recently recognized to improve the symptoms in patients with interstitial cystitis (IC), in a rat model of HCl-induced chronic cystitis, to elucidate the possible mechanisms by which the drug improves the symptoms of IC. MATERIALS AND METHODS: Chronic cystitis was induced by intravesical instillation of 0.2 mL of 0.4 m HCl in female adult rats. After a once-daily oral administration of IPD-1151T (0.1-100 mg/kg) or prednisolone (5 mg/kg) for 7 days, cystometry was performed under urethane anaesthesia. The bladder from HCl-induced cystitis rats was also assessed histopathologically. RESULTS: On cystometrography there was frequent voiding in cystitis rats. Administration of IPD-1151T for 7 days after intravesical HCl instillation dose-dependently increased the micturition volume and intercontraction intervals. Treatment with prednisolone had similar therapeutic effects. Histological analyses in the bladder from cystitis rats revealed oedema and infiltration of inflammatory cells such as mast cells and eosinophils in the lamina propria and the transitional epithelial thickening. These histological changes and the number of mast cells and eosinophils were reduced by administration of IPD-1151T or prednisolone. CONCLUSION: The present results indicate that IPD-1151T improves bladder function and pathological changes in HCl-induced cystitis rats, as previously observed in patients with IC. The rat cystitis model induced by HCl could provide useful information for studying proposed therapies for IC which might involve T cell-dependent inflammatory responses as one of its potential pathophysiologies.

Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid. Publishing Authors By Initials

T Kirimoto,K Nakano,K Irimura,Y Hayashi,N Matsuura,M Kiniwa,T Oka,N Yoshimura,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

PUBMED ID PMID:

MEDLINE DATE:

Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: BJU international

VOLUME: 100

Page Numbers: 935-9

Journal Abbreviation: BJU Int.

ISSN: 1464-4096

DAY: 20

MONTH: 08

YEAR: 2007

Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100886721

Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: pathology

Chemical & Substance for Abstract: Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid. Information

Substance Name: suplatast tosilate

Registry Number: 94055-76-2

Grant and Affiliation Information for Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid.

AFFILIATION: Taiho Pharmaceutical Co., Ltd, Tokushima Research Center, Optimal Medication Research Laboratory, Tokushima, Japan. t-kirimoto@taiho.co.jp

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: BJU Int

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Beneficial effects of suplatast tosilate IPD-1151T in a rat cystitis model induced by intravesical hydrochloric acid Related Publications

• A nested case-control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3.
• A prospective study of green tea consumption and oral cancer incidence in Japan.
• Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid.
• Characterization of wound drainage fluids as a source of soluble factors associated with wound healing: comparison with platelet-rich plasma and potential use in cell culture.
• Circadian clock genes and photoperiodism: Comprehensive analysis of clock gene expression in the mediobasal hypothalamus, the suprachiasmatic nucleus, and the pineal gland of Japanese Quail under various light schedules.
• Effects of IP-751, ajulemic acid, on bladder overactivity induced by bladder irritation in rats.
• Effects of anaesthesia on the nitrergic pathway during the micturition reflex in rats.
• Follow-up results of 71 patients undergoing metallic stent placement for the treatment of a malignant obstruction of the superior vena cava.
• Functional analysis of active urethral closure mechanisms under sneeze induced stress condition in a rat model of birth trauma.
• Further evidence that major outer membrane proteins homologous to OmpA in Porphyromonas gingivalis stabilize bacterial cells.
• Herpes simplex virus vector-mediated delivery of glial cell line-derived neurotrophic factor rescues erectile dysfunction following cavernous nerve injury.
• Histone deacetylase inhibitor-induced glycodelin enhances the initial step of implantation.
• Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells.
• Inhibitory roles of peripheral nitrergic mechanisms in capsaicin-induced detrusor overactivity in the rat.
• Interobserver variation in the histopathological assessment of nonalcoholic steatohepatitis.
• Isoform-specific enhancement of adenylyl cyclase activity by n-alkanols.
• Local effects of antimuscarinics.
• Lower urinary tract symptoms (LUTS) and bladder afferent activity.
• Mortality attributable to cigarette smoking in a cohort study in Japan.
• Neurophysiology of stress urinary incontinence.
• Novel mutations in the GRK1 gene in Japanese patients With Oguchi disease.
• Odor-intensity Coding in the Anterior Piriform Cortex.
• Polypoidal choroidal vasculopathy examined with en face optical coherence tomography.
• Reduction of aluminum toxicity by 2-isopropylmalic acid in the budding yeast Saccharomyces cerevisiae.
• Retinal pigment epithelial tear in polypoidal choroidal vasculopathy.
• Rice gibberellin-insensitive dwarf mutant gene Dwarf 1 encodes the alpha-subunit of GTP-binding protein.
• Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats.
• The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder.
• The effect of dendritic cells on the retinal cell transplantation.
• Torquetenovirus infection among northeastern Thai blood donors.