Behavioral teratogenicity induced by nonforced maternal nicotine consumption.

Behavioral teratogenicity induced by nonforced maternal nicotine consumption. Research Abstract Details 

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Behavioral teratogenicity induced by nonforced maternal nicotine consumption. Abstract Text:

Rodrigo Paz,Brigg Barsness,Trevor Martenson,Daniel Tanner,Andrea M Allan,

Prenatal nicotine exposure (PNE) has been associated with increased prevalence of attention deficit hyperactivity disorder (ADHD), major depressive disorder (MDD) and substance abuse in exposed children and adolescents. Whether these syndromes are caused by nicotine exposure, or genetic and psychosocial adversities associated with maternal smoking is not completely clear. Animal models suggest a direct impact of PNE. However, the fact that nicotine is forcefully administrated in these paradigms raises some questions about the specificity of these findings. Pregnant C57BI/6J mice were allowed to choose drinking saccharin/nicotine solutions or pure water. Controls could choose saccharin solutions or pure water. Offspring were tested in spontaneous locomotion, fear-associated learning (trace conditioning), addictive (conditioned place preference), and depression-like (learned helplessness) behaviors. There was no significant difference in weight or pup number between the prenatal treatment groups. A significant effect of PNE was observed on spontaneous locomotion, preference for a cocaine-associated place, and latency to escape in the learned helplessness paradigm. Surprisingly, PNE mice exhibited an increased learning of trace-conditioned fear-associated cues. The hyperlocomotive behavior reported in animal models of PNE is not likely an artifact of forceful nicotine administration. The increased prevalence of ADHD, MDD and substance abuse observed in PNE children and adolescents is probably caused by direct behavioral teratogenic effects of PNE. The role of PNE as a risk factor of syndromes associated to increased learning of fear-associated cues such as post-traumatic stress disorder (PTSD) warrants further evaluation.

Behavioral teratogenicity induced by nonforced maternal nicotine consumption. Publishing Authors By Initials

R Paz,B Barsness,T Martenson,D Tanner,AM Allan,

For similar epidemiologic factors: sex factors research abstracts see: epidemiologic factors: sex factors research

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Behavioral teratogenicity induced by nonforced maternal nicotine consumption. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuropsychopharmacology : official publication of

VOLUME: 32

Page Numbers: 693-9

Journal Abbreviation: Neuropsychopharmacology

ISSN: 0893-133X

DAY: 22

MONTH: 03

YEAR: 2006

Behavioral teratogenicity induced by nonforced maternal nicotine consumption. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8904907

Behavioral teratogenicity induced by nonforced maternal nicotine consumption. Keywords Mesh Terms:

KEYWORDS: Sex Factors

MESH TERMS: toxicity

Chemical & Substance for Abstract: Behavioral teratogenicity induced by nonforced maternal nicotine consumption. Information

Substance Name: Nicotine

Registry Number: 54-11-5

Grant and Affiliation Information for Behavioral teratogenicity induced by nonforced maternal nicotine consumption.

AFFILIATION: Department of Neurosciences, University of New Mexico, Albuquerque, NM 87131-0001, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: ES P30-012072-05

ACRONYM: ES

MEDLINETA: Neuropsychopharmacology

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