Behavioral genetics of caenorhabditis elegans unc-103-encoded erg-like K(+) channel.

Behavioral genetics of caenorhabditis elegans unc-103-encoded erg-like K(+) channel. Research Abstract Details 

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Behavioral genetics of caenorhabditis elegans unc-103-encoded erg-like K(+) channel. Abstract Text:

David J Reiner,David Weinshenker,Hong Tian,James H Thomas,Kiyoji Nishiwaki,Johji Miwa,Todd Gruninger,Brigitte Leboeuf,L Rene Garcia,

The Caenorhabditis elegans unc-103 gene encodes a potassium channel whose sequence is most similar to the ether-a-go-go related gene (erg) type of K+ channels. We find that the n 500 and e 1597 gain-of-function (gf) mutations in unc-103 cause reduced excitation in most muscles, while loss-of-function (lf) mutations cause mild muscle hyper-excitability. Both gf alleles change the same residue near the cytoplasmic end of S6, consistent with this region regulating channel activation. We also report additional dominant-negative and lf alleles of unc-103 that can antagonize or reduce the function of both gf and wild-type alleles. The unc-103 locus contains 6 promoter regions that express unc-103 in different combinations of body-wall and sex-specific muscles, motor-, inter- and sensory-neurons. Each promoter drives transcripts containing a unique first exon, conferring sequence variability to the N-terminus of the UNC-103 protein, while three splice variants introduce variability into the UNC-103 C-terminus. unc-103(0) hermaphrodites prematurely lay embryos that would normally be retained in the uterus and lay eggs under conditions that inhibit egg-laying behavior. In the egg-laying circuit, unc-103 is expressed in vulval muscles and the HSN neurons from different promoters. Supplying the proper UNC-103 isoform to the vulval muscles is sufficient to restore regulation to egg-laying behavior.

Behavioral genetics of caenorhabditis elegans unc-103-encoded erg-like K(+) channel. Publishing Authors By Initials

DJ Reiner,D Weinshenker,H Tian,JH Thomas,K Nishiwaki,J Miwa,T Gruninger,B Leboeuf,LR Garcia,

For similar reproductive and urinary physiology: reproduction research abstracts see: reproductive and urinary physiology: reproduction research

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Behavioral genetics of caenorhabditis elegans unc-103-encoded erg-like K(+) channel. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neurogenetics

VOLUME: 20

Page Numbers: 41-66

Journal Abbreviation: J. Neurogenet.

ISSN: 0167-7063

DAY: 3

MONTH: 12

YEAR: 2007

Behavioral genetics of caenorhabditis elegans unc-103-encoded erg-like K(+) channel. Information

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LANGUAGE: eng

NlmUniqueID: 8406473

Behavioral genetics of caenorhabditis elegans unc-103-encoded erg-like K(+) channel. Keywords Mesh Terms:

KEYWORDS: Reproduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Behavioral genetics of caenorhabditis elegans unc-103-encoded erg-like K(+) channel. Information

Substance Name: UNC-103 protein, C elegans

Registry Number: NM_065423

Grant and Affiliation Information for Behavioral genetics of caenorhabditis elegans unc-103-encoded erg-like K(+) channel.

AFFILIATION: Department of Genome Sciences, University of Washington, Seattle, WA, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS-30187

ACRONYM: NS

MEDLINETA: J Neurogenet

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