Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration.

Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration. Research Abstract Details 

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Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration. Abstract Text:

Songhee Jeon,Nan Hyung Kim,Byung Soo Koo,Hyun Joo Lee,Ai Young Lee,Songhee Jeon,Nan Hyung Kim,Byung Soo Koo,Hyun Joo Lee,Ai Young Lee,Songhee Jeon,Nan Hyung Kim,Byung Soo Koo,Hyun Joo Lee,Ai Young Lee,

Pigmentation may result from melanocyte proliferation, melanogenesis, migration or increases in dendricity. Recently, it has been reported that secreted phospholipase A(2)(sPLA(2)) known as a component of bee venom (BV), stimulates melanocyte dendricity and pigmentation. BV has been used clinically to control rheumatoid arthritis and to ameliorate pain via its anti-inflammatory and antinociceptive properties. Moreover, after treatment with BV, pigmentation around the injection sites was occasionally observed and the pigmentation lasted a few months. However, no study has been done about the effect of BV on melanocytes. Thus, in the present study, we examined the effect of BV on the proliferation, melanogenesis, dendricity and migration in normal human melanocytes and its signal transduction. BV increased the number of melanocytes dose and time dependently through PKA, ERK, and PI3K/Akt activation. The level of cAMP was also increased by BV treatment. Moreover, BV induced melanogenesis through increased tyrosinase expression. Furthermore, BV induced melanocyte dendricity and migration through PLA(2) activation. Overall, in this study, we demonstrated that BV may have an effect on the melanocyte proliferation, melanogenesis, dendricity and migration through complex signaling pathways in vitro, responsible for the pigmentation. Thus, our study suggests a possibility that BV may be developed as a therapeutic drug for inducing repigmentation in vitiligo skin.

Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration. Publishing Authors By Initials

S Jeon,NH Kim,BS Koo,HJ Lee,AY Lee,S Jeon,NH Kim,BS Koo,HJ Lee,AY Lee,S Jeon,NH Kim,BS Koo,HJ Lee,AY Lee,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental & molecular medicine

VOLUME: 39

Page Numbers: 603-13

Journal Abbreviation: Exp. Mol. Med.

ISSN: 1226-3613

DAY: 31

MONTH: Oct

YEAR: 2007

Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration. Information

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LANGUAGE: eng

NlmUniqueID: 9607880

Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: drug effects

Chemical & Substance for Abstract: Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration. Information

Substance Name: Monophenol Monooxygenase

Registry Number: EC 1.14.18.1

Grant and Affiliation Information for Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration.

AFFILIATION: Dongguk University Research Institute of Biotechnology, Medical Science Research Center, Goyang 410-773, Korea.

Country: Korea (South)

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MEDLINETA: Exp Mol Med

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