Bcl2 Negatively Regulates DNA Double-Strand-Break Repair through a Nonhomologous End-Joining Pathway.

Bcl2 Negatively Regulates DNA Double-Strand-Break Repair through a Nonhomologous End-Joining Pathway. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Bcl2 Negatively Regulates DNA Double-Strand-Break Repair through a Nonhomologous End-Joining Pathway. Abstract Text:

Qinhong Wang,Fengqin Gao,W Stratford May,Yangde Zhang,Tammy Flagg,Xingming Deng,

Bcl2 can enhance susceptibility to carcinogenesis, but the mechanism(s) remains fragmentary. Here we discovered that Bcl2 suppresses DNA double-strand-break (DSB) repair and V(D)J recombination by downregulating Ku DNA binding activity, which is associated with increased genetic instability. Exposure of cells to ionizing radiation enhances Bcl2 expression in the nucleus, which interacts with both Ku70 and Ku86 via its BH1 and BH4 domains. Removal of the BH1 or BH4 domain abrogates the inhibitory effect of Bcl2 on Ku DNA binding, DNA-PK, and DNA end-joining activities, which results in the failure of Bcl2 to block DSB repair as well as V(D)J recombination. Intriguingly, Bcl2 directly disrupts the Ku/DNA-PKcs complex in vivo and in vitro. Thus, Bcl2 suppression of the general DSB repair and V(D)J recombination may occur in a mechanism by inhibiting the nonhomologous end-joining pathway, which may lead to an accumulation of DNA damage and genetic instability.

Bcl2 Negatively Regulates DNA Double-Strand-Break Repair through a Nonhomologous End-Joining Pathway. Publishing Authors By Initials

Q Wang,F Gao,WS May,Y Zhang,T Flagg,X Deng,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Bcl2 Negatively Regulates DNA Double-Strand-Break Repair through a Nonhomologous End-Joining Pathway. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular cell

VOLUME: 29

Page Numbers: 488-98

Journal Abbreviation: Mol. Cell

ISSN: 1097-2765

DAY: 29

MONTH: Feb

YEAR: 2008

Bcl2 Negatively Regulates DNA Double-Strand-Break Repair through a Nonhomologous End-Joining Pathway. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9802571

Bcl2 Negatively Regulates DNA Double-Strand-Break Repair through a Nonhomologous End-Joining Pathway. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Bcl2 Negatively Regulates DNA Double-Strand-Break Repair through a Nonhomologous End-Joining Pathway. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Bcl2 Negatively Regulates DNA Double-Strand-Break Repair through a Nonhomologous End-Joining Pathway.

AFFILIATION: UF Shands Cancer Center, University of Florida, Gainesville, FL 32610-3633, USA; Department of Medicine, University of Florida, Gainesville, FL 32610-3633, USA; Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610-3633, USA

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Mol Cell

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Bcl2 Negatively Regulates DNA Double-Strand-Break Repair through a Nonhomologous End-Joining Pathway Related Publications

• Association analyses of CYP19 gene polymorphisms with height variation in a large sample of Caucasian nuclear families.
• Asymmetric Friedel-crafts reaction of indoles with imines by an organic catalyst.
• Asymmetric synthesis of chiral aldehydes by conjugate additions with bifunctional organocatalysis by cinchona alkaloids.
• Diagnosis of interstitial lung disease in patients with connective tissue disease by the diffusing capacity of carbon monoxide.
• The Mannich reaction of malonates with simple imines catalyzed by bifunctional cinchona alkaloids: enantioselective synthesis of beta-amino acids.
• [A preliminary report of SARS coronavirus specific RNA in SARS convalescents and medical person]
• [A simple method for the determination of tungsten ores by XRF spectrometer]
• [A986S polymorphism of calcium-sensing receptor gene is not related to bone mineral density or bone size in premenopausal Chinese women]
• [Analysis of acute physiology and chronic health evaluation III in the 54 patients with severe acute respiratory syndrome]
• [Association of serum leptin and insulin resistance with nonalcoholic fatty liver disease]
• [Characteristics and Influencing factors of Sperm Interaction with Exogenous DNA]
• [Clinical study of P-gp, and bcl-2 protein expression in non-Hodgkin's lymphomas patients]
• [Color reaction of new tailed porphyrin-pyridine quaternary ammonium salts with copper (II)]
• [Curative effect of cyclic adenosine monophosphate and Shengmai injection on the aged patients with sinus bradycardia]
• [Determination of total organic acids in wine by interfacial derivatization gas chromatographic method]
• [Development of measurement and control technologies for hyperthermia treatments of tumors with AC magnetic field]
• [Direct simultaneous determination of o, m, p-nitronethylbenzene in mixture using spectrophotometry combined with Kalman filter]
• [Endoscope-assisted thyroidectomy by chest approach with good cosmetic results]
• [Environmental control and life support system of spacecraft]
• [Epidemiological study on taeniasis and cysticercosis in Shandong Province]
• [Finite element analysis of DAI animal model caused by nonimpact with half bound head in cats]
• [Immediate implantation and immediate restoration]
• [Infrared absorption spectroscopy of optical waveguide in proton-exchanged LiNbO3]
• [Mechanism of the WNT family in vertebrate skeleton development]
• [Modulation effects of recombinant human growth hormone on postburn hypermetabolism in burn patients]
• [Pathologic diagnosis and classification of vasculitis]
• [Survey of toxoplasma infection in fertile age women and children in Urumqi city]
• [The carcinogenesis of human cytomegalovirus to mouse cervix]
• [The inflammatory-inhibition and immunoregulation effects of alpha melanocyte stimulating hormone]
• [Treatment analysis of 32 cases with sepsis]