BCG-malaria co-Infection has paradoxical effects on C57BL/6 and A/J mouse strains.

BCG-malaria co-Infection has paradoxical effects on C57BL/6 and A/J mouse strains. Research Abstract Details 

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BCG-malaria co-Infection has paradoxical effects on C57BL/6 and A/J mouse strains. Abstract Text:

A L Leisewitz,K Rockett,D Kwiatkowski,

Bacillus Calmette-Guérin (BCG) infection of the spleen is a potent modifier of splenic function. Prior to malaria infection, we infected two mouse strains of differing susceptibility to Plasmodium chabaudi AS (C57BL/6 and A/J) with this mycobacterium. We then evaluated aspects of spleen cell composition, architecture and cytokine expression, and correlated these with the outcome. BCG preinfection resulted in protection of the A/J mice but paradoxically resulted in mortality of the C57BL/6 mice. The latter developed higher parasitaemias that peaked earlier than the A/J mice rendered resistant by BCG. BCG infection induced remarkable changes to splenic histology examined by H&E staining, but there were no consistent differences between mouse strains. C57BL/6 mice had higher absolute numbers of all immune cell phenotypes than did A/J mice, and higher macrophage and dendritic cell proportions. BCG-induced resistance in A/J mice was associated with an increased CD4(+) expression of IFN-gamma whilst induced death in C57BL/6 mice was associated with excessive IFN-gamma expression. A moderate TH1 response in the A/J model may have been responsible for the improved survival, and an excessive TH1 response in the C57BL/6 model may have contributed to their death.

BCG-malaria co-Infection has paradoxical effects on C57BL/6 and A/J mouse strains. Publishing Authors By Initials

AL Leisewitz,K Rockett,D Kwiatkowski,

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BCG-malaria co-Infection has paradoxical effects on C57BL/6 and A/J mouse strains. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Parasite immunology

VOLUME: 30

Page Numbers: 1-12

Journal Abbreviation: Parasite Immunol.

ISSN: 0141-9838

DAY: 18

MONTH: Jan

YEAR: 2008

BCG-malaria co-Infection has paradoxical effects on C57BL/6 and A/J mouse strains. Information

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LANGUAGE: eng

NlmUniqueID: 7910948

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Grant and Affiliation Information for BCG-malaria co-Infection has paradoxical effects on C57BL/6 and A/J mouse strains.

AFFILIATION: Department of Veterinary Tropical Diseases, Onderstepoort, South Africa.

Country: England

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MEDLINETA: Parasite Immunol

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