Bayesian Hierarchical Modeling of Receptor Occupancy in PET Trials.

Bayesian Hierarchical Modeling of Receptor Occupancy in PET Trials. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Bayesian Hierarchical Modeling of Receptor Occupancy in PET Trials. Abstract Text:

F Vandenhende,D Renard,Y Nie,A Kumar,J Miller,J Tauscher,J Witcher,Y Zhou,D F Wong,

Receptor occupancy (RO) PET is a non-invasive way to determine drug on target. Given the complexity of procedures, long acquisition times, and high cost, ligand displacement imaging trials often have a limited size and produce sparse RO results over the time course of the blocking drug. To take the best advantage of the available data, we propose a Bayesian hierarchical model to analyze RO as a function of the displacing drug. The model has three components: the first estimates RO using brain regional time-radioactivity concentrations, the second shapes the pharmacokinetic profile of the blocking drug, and the last relates PK to RO. Compared to standard 2-steps RO estimation methods, our Bayesian approach quantifies the variability of the individual RO measures. The model has also useful prediction capabilities: to quantify brain RO for dosage regimens of the drug that were not tested in the experiment. This permits the optimal dose selection of neuroscience drugs at a limited cost. We illustrate the method in the prediction of RO after multiple dosing from a single-dose trial.

Bayesian Hierarchical Modeling of Receptor Occupancy in PET Trials. Publishing Authors By Initials

F Vandenhende,D Renard,Y Nie,A Kumar,J Miller,J Tauscher,J Witcher,Y Zhou,DF Wong,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Bayesian Hierarchical Modeling of Receptor Occupancy in PET Trials. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biopharmaceutical statistics

VOLUME: 18

Page Numbers: 256-72

Journal Abbreviation:

ISSN: 1520-5711

DAY: 10

MONTH: 03

YEAR: 2008

Bayesian Hierarchical Modeling of Receptor Occupancy in PET Trials. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9200436

Bayesian Hierarchical Modeling of Receptor Occupancy in PET Trials. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Bayesian Hierarchical Modeling of Receptor Occupancy in PET Trials. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Bayesian Hierarchical Modeling of Receptor Occupancy in PET Trials.

AFFILIATION: Global Statistics, Lilly Research Laboratories, Mont-Saint-Guibert, Belgium.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biopharm Stat

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Bayesian Hierarchical Modeling of Receptor Occupancy in PET Trials Related Publications

• A simple microindentation technique for mapping the microscale compliance of soft hydrated materials and tissues.
• A study of density of states and ground states in hydrophobic-hydrophilic protein folding models by equi-energy sampling.
• An extended simplified reference tissue model for the quantification of dynamic PET with amphetamine challenge.
• Cell cycle dysregulation in oral cancer.
• Characterization of a transglycosylase domain of Streptococcus pneumoniae PBP1b.
• Differentially expressed protein markers in human submandibular and sublingual secretions.
• Dose effects of triazolam on brain activity during episodic memory encoding: a PET study.
• Driver perception response time during the signal change interval.
• Expression of cell-cycle regulator CDK2-associating protein 1 (p12CDK2AP1) in transgenic mice induces testicular and ovarian atrophy in vivo.
• Extracellular heat shock protein-70 induces endotoxin tolerance in THP-1 cells.
• Feruloyl esterase: a key enzyme in biomass degradation.
• German cockroach proteases regulate matrix metalloproteinase-9 in human bronchial epithelial cells.
• HIV Evolution and Escape.
• Health services utilization for people with HIV infection: comparison of a population targeted for outreach with the U.S. population in care.
• In vivo imaging reveals dendritic targeting of laminated afferents by zebrafish retinal ganglion cells.
• In vivo optical coherence tomography of the nasal mucosa.
• Measurement of serum D-arabinitol/creatinine ratios for initial diagnosis and for predicting outcome in an unselected, population-based sample of patients with Candida fungemia.
• Mechanism and function of heat shock-dependent IkappaBalpha expression.
• Mycotic aortic aneurysm following treatment of pyogenic vertebral osteomyelitis.
• Prediction of breast cancer using volatile biomarkers in the breath.
• Prolonged and severe dysphagia following anterior cervical surgery.
• Sugar-assisted ligation of N-linked glycopeptides with broad sequence tolerance at the ligation junction.
• The executive clock drawing task (CLOX) is a poor screening test for executive dysfunction in Chinese elderly patients with subcortical ischemic vascular disease.
• The relationship between parent emotion, parent behavior, and health status of young African American and Latino children.
• [Advances of fine needle aspiration cytology]
• [Biosynthesis and characterization of jarosite]
• [Creation of the World Federation of Critical Care Nursing (WFCCN)]
• [Effect of oxygen on the fluorescence of sol-gel with ruthenium complexes]
• [In Process Citation]
• c-Jun NH(2)-terminal kinase 2alpha2 promotes the tumorigenicity of human glioblastoma cells.