Basic fibroblast growth factor modulates proliferation and collagen expression in urinary bladder smooth muscle cells.

Basic fibroblast growth factor modulates proliferation and collagen expression in urinary bladder smooth muscle cells. Research Abstract Details 

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Basic fibroblast growth factor modulates proliferation and collagen expression in urinary bladder smooth muscle cells. Abstract Text:

Masaaki Imamura,Akihiro Kanematsu,Shingo Yamamoto,Yu Kimura,Isao Kanatani,Noriyuki Ito,Yasuhiko Tabata,Osamu Ogawa,

Bladder hypertrophy is a general consequence of bladder outlet obstruction (BOO) and a typical phenomenon observed in clinical urologic diseases such as benign prostatic hyperplasia and neurogenic bladder. It is characterized by smooth muscle hyperplasia, altered extracellular matrix composition, and increased contractile function. Various growth factors are likely involved in hypertrophic pathophysiology, but their functions remain unknown. In this report, the role of basic fibroblast growth factor (bFGF) was investigated using a rat bladder smooth muscle cell (BSMC) culture system and an original animal model, in which bFGF was released from a gelatin hydrogel directly onto rat bladders. bFGF treatment promoted BSMC proliferation both in vitro and in vivo. In vitro, bFGF downregulated the expression of type I collagen, but upregulated type III collagen. ERK1/2, but not p38MAPK, was activated by bFGF, whereas inhibition of ERK1/2 by PD98059 reversed bFGF-induced BSMC proliferation, type I collagen downregulation, and type III collagen upregulation. In the in vivo release model, bFGF upregulated type III collagen and increased the contractile force of treated bladders. In parallel with these findings, hypertrophied rat bladders created by urethral constriction showed increased urothelial bFGF expression, BSMC proliferation, and increased type III collagen expression compared with sham-operated rats. These data suggest that bFGF from the urothelium could act as a paracrine signal that stimulates the proliferation and matrix production of BSMC, thereby contributing to the hypertrophic remodeling of the smooth muscle layer.

Basic fibroblast growth factor modulates proliferation and collagen expression in urinary bladder smooth muscle cells. Publishing Authors By Initials

M Imamura,A Kanematsu,S Yamamoto,Y Kimura,I Kanatani,N Ito,Y Tabata,O Ogawa,

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Basic fibroblast growth factor modulates proliferation and collagen expression in urinary bladder smooth muscle cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Renal physiology

VOLUME: 293

Page Numbers: F1007-17

Journal Abbreviation: Am. J. Physiol. Renal Physiol.

ISSN: 0363-6127

DAY: 18

MONTH: 07

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Basic fibroblast growth factor modulates proliferation and collagen expression in urinary bladder smooth muscle cells.

AFFILIATION: Department of Urology, Graduate School of Medicine, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.

Country: United States

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MEDLINETA: Am J Physiol Renal Physiol

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