Basic fibroblast growth factor enema improves experimental colitis in rats.

Basic fibroblast growth factor enema improves experimental colitis in rats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Basic fibroblast growth factor enema improves experimental colitis in rats. Abstract Text:

Tetsu Kojima,Toshiahi Watanabe,Keisuke Hata,Hirokazu Nagawa,Tetsu Kojima,Toshiahi Watanabe,Keisuke Hata,Hirokazu Nagawa,

BACKGROUND/AIMS: Growth factors have a potential role in gastrointestinal mucosal repair. Although basic fibroblast growth factor (bFGF) is known to contribute to wound healing, however, the role of bFGF in the treatment of inflammatory bowel disease has not been established. The aim of this study is to investigate the therapeutic effects of intracolonic bFGF administration on both the clinical symptoms and histological mucosal repair in an experimental model of colitis in rats. METHODOLOGY: Acute colitis was induced with 5% dextran sulfate sodium (DSS) given for one week in drinking water. The rats were treated daily with recombinant human bFGF enema (400 microg/kg/day) or vehicle once daily from day 1 to day 7. Clinical score (stool consistency, weight loss and hemoccult/gross rectal bleeding), colon length and histological score of mucosal injury in colonic tissue samples were analyzed. RESULTS: Administration of bFGF enema significantly reduced clinical score (p < 0.01) and histological score (p < 0.01). No specific side effect of bFGF was noted. CONCLUSIONS: These results suggest that bFGF enema is clinically safe and useful in the treatment of inflammatory bowel disease. BFGF enema may contribute as a novel therapy of IBD.

Basic fibroblast growth factor enema improves experimental colitis in rats. Publishing Authors By Initials

T Kojima,T Watanabe,K Hata,H Nagawa,T Kojima,T Watanabe,K Hata,H Nagawa,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Basic fibroblast growth factor enema improves experimental colitis in rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Hepato-gastroenterology

VOLUME: 54

Page Numbers: 1373-7

Journal Abbreviation: Hepatogastroenterology

ISSN: 0172-6390

DAY: 21

MONTH: 08

YEAR: 2007

Basic fibroblast growth factor enema improves experimental colitis in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8007849

Basic fibroblast growth factor enema improves experimental colitis in rats. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Basic fibroblast growth factor enema improves experimental colitis in rats. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Basic fibroblast growth factor enema improves experimental colitis in rats.

AFFILIATION: Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Japan. kojimat-tky@umin.ac.jp

Country: Greece

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Hepatogastroenterology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Basic fibroblast growth factor enema improves experimental colitis in rats Related Publications

• A study of dendritic and endothelial cell interactions in colon cancer in a cell line and small mammal model.
• Apoptosis induction by p38 MAPK inhibitor in human colon cancer cells.
• Basic fibroblast growth factor enema improves experimental colitis in rats.
• Chronic expanding hematoma in combination with a pseudoaneurysm: a case report.
• Clinical challenges and images in GI. Amoebic appendicitis.
• DNA methylation and sensitivity to antimetabolites in cancer cell lines.
• Early gastric cancer shows different associations with adipose tissue volume depending on histological type.
• Epigallocatechin gallate affects human dendritic cell differentiation and maturation.
• Good correlation between cerebral oxygenation measured using near infrared spectroscopy and stump pressure during carotid clamping.
• Heating and coagulation volume obtained with high-intensity focused ultrasound therapy: comparison of perflutren protein-type A microspheres and MRX-133 in rabbits.
• Hyperglycemia and hypertriglyceridemia may associate with the adenoma-carcinoma transition in colorectal epithelial cells.
• Isolated spontaneous dissection of the splanchnic arteries.
• Left-Sided microsatellite unstable colorectal cancers show less frequent methylation of hMLH1 and CpG island methylator phenotype than right-sided ones.
• Leptin augments proliferation of breast cancer cells via transactivation of HER2.
• Loss of Smad4 protein expression and 18qLOH as molecular markers indicating lymph node metastasis in colorectal cancer-a study matched for tumor depth and pathology.
• Metastatic esophageal tumor from cecal carcinoma.
• Nuclear translocation of HER-4/c-erbB-4 is significantly correlated with prognosis of esophageal squamous cell carcinoma.
• Pilot study of anti-angiogenic vaccine using fixed whole endothelium in patients with progressive malignancy after failure of conventional therapy.
• Poorly differentiated colorectal adenocarcinomas show higher rates of microsatellite instability and promoter methylation of p16 and hMLH1: A study matched for T classification and tumor location.
• Preoperative radiation response evaluated by 18-fluorodeoxyglucose positron emission tomography predicts survival in locally advanced rectal cancer.
• Silencing of secreted frizzled-related protein genes in MSI colorectal carcinogenesis.