Basic design and synthesis of sulfonated contrast agents for magnetic resonance imaging based on gadolinium complexes.

Basic design and synthesis of sulfonated contrast agents for magnetic resonance imaging based on gadolinium complexes. Research Abstract Details 

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Basic design and synthesis of sulfonated contrast agents for magnetic resonance imaging based on gadolinium complexes. Abstract Text:

Hiroki Hifumi,Akihiro Tanimoto,Aki Honda,Daniel Citterio,Koji Suzuki,Hiroki Hifumi,Akihiro Tanimoto,Aki Honda,Daniel Citterio,Koji Suzuki,Hiroki Hifumi,Akihiro Tanimoto,Aki Honda,Daniel Citterio,Koji Suzuki,

Magnetic resonance angiography (MRA) is an imaging method to examine blood vessels based on the magnetic resonance imaging (MRI) technique. For this purpose, blood pool contrast agents have been developed to selectively increase the signal intensity of the intravascular lumen for improvement of the contrast-to-noise ratio in MR images. Here, we describe the design and the syntheses of six novel sulfonated contrast agents (KMR-Sulfo1 - 6), their chemical properties and their in vivo applications. In this study, we investigated the lipophilicity and the hydrophilicity of a gadolinium complex using a convenient two-step synthesis route, with the goal of prolonging the plasma half-life by binding mainly to human serum albumin. We confirmed that KMR-Sulfo5 fulfilled the requirements as a blood pool contrast agent: it showed a sufficient relaxivity r(1) of 5.9 mM(-1) s(-1), a long plasma half-life of 25.7 min and complete elimination from the body within 12 h after the administration.

Basic design and synthesis of sulfonated contrast agents for magnetic resonance imaging based on gadolinium complexes. Publishing Authors By Initials

H Hifumi,A Tanimoto,A Honda,D Citterio,K Suzuki,H Hifumi,A Tanimoto,A Honda,D Citterio,K Suzuki,H Hifumi,A Tanimoto,A Honda,D Citterio,K Suzuki,

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Basic design and synthesis of sulfonated contrast agents for magnetic resonance imaging based on gadolinium complexes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Analytical sciences : the international journal of

VOLUME: 23

Page Numbers: 1159-65

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ISSN: 0910-6340

DAY: 11

MONTH: Oct

YEAR: 2007

Basic design and synthesis of sulfonated contrast agents for magnetic resonance imaging based on gadolinium complexes. Information

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LANGUAGE: eng

NlmUniqueID: 8511078

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Grant and Affiliation Information for Basic design and synthesis of sulfonated contrast agents for magnetic resonance imaging based on gadolinium complexes.

AFFILIATION: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama 223-8522, Japan.

Country: Japan

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MEDLINETA: Anal Sci

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