Base excision repair sensitizes cells to sulfur mustard and chloroethyl ethyl sulfide.

Base excision repair sensitizes cells to sulfur mustard and chloroethyl ethyl sulfide. Research Abstract Details 

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Base excision repair sensitizes cells to sulfur mustard and chloroethyl ethyl sulfide. Abstract Text:

Zdenka Matijasevic,Michael R Volkert,

DNA repair generally functions to improve survival and reduce mutagenesis of cells that have suffered DNA damage. In this study we examine the role of nucleotide excision repair (NER) and base excision repair (BER) in recovery, mutagenesis and DNA repair in response to DNA damage inflicted by the mustard compounds, sulfur mustard (SM) and chloroethyl ethyl sulfide (CEES) in bacteria and mammalian cells. SM and CEES are compared because SM produces cross-links and monoadducts, whereas CEES produces only monoadducts that are similar to those produced by SM, thus allowing the examination of which types of lesions may be responsible for the effects seen. We find that the presence of a functional NER pathway increases survival and reduces mutagenesis, whereas the presence of a functional BER pathway reduces survival, increases mutagenesis, and decreases repair. The deleterious effects of BER appear to be due to an interaction between the DNA glycosylases and the lesions produced by SM and CEES. Possible mechanisms for BER-mediated sensitization by glycosylase action on mustard lesions are discussed.

Base excision repair sensitizes cells to sulfur mustard and chloroethyl ethyl sulfide. Publishing Authors By Initials

Z Matijasevic,MR Volkert,

For similar genetic processes: mutagenesis research abstracts see: genetic processes: mutagenesis research

PUBMED ID PMID:

MEDLINE DATE:

Base excision repair sensitizes cells to sulfur mustard and chloroethyl ethyl sulfide. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: DNA repair

VOLUME: 6

Page Numbers: 733-41

Journal Abbreviation:

ISSN: 1568-7864

DAY: 9

MONTH: 02

YEAR: 2007

Base excision repair sensitizes cells to sulfur mustard and chloroethyl ethyl sulfide. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101139138

Base excision repair sensitizes cells to sulfur mustard and chloroethyl ethyl sulfide. Keywords Mesh Terms:

KEYWORDS: Mutagenesis

MESH TERMS: toxicity

Chemical & Substance for Abstract: Base excision repair sensitizes cells to sulfur mustard and chloroethyl ethyl sulfide. Information

Substance Name: DNA Glycosylases

Registry Number: EC 3.2.2.-

Grant and Affiliation Information for Base excision repair sensitizes cells to sulfur mustard and chloroethyl ethyl sulfide.

AFFILIATION: Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue, North Worcester, MA 01655, United States.

Country: Netherlands

AGENCY: United States NCI

GRANT: CA100122

ACRONYM: CA

MEDLINETA: DNA Repair (Amst)

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