Barrier function and cytologic features of the ocular surface epithelium after autologous cultivated oral mucosal epithelial transplantation.

Barrier function and cytologic features of the ocular surface epithelium after autologous cultivated oral mucosal epithelial transplantation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Barrier function and cytologic features of the ocular surface epithelium after autologous cultivated oral mucosal epithelial transplantation. Abstract Text:

Yoshiyuki Satake,Murat Dogru,Gen-Yuki Yamane,Shigeru Kinoshita,Kazuo Tsubota,Jun Shimazaki,Yoshiyuki Satake,Murat Dogru,Gen-Yuki Yamane,Shigeru Kinoshita,Kazuo Tsubota,Jun Shimazaki,Yoshiyuki Satake,Murat Dogru,Gen-Yuki Yamane,Shigeru Kinoshita,Kazuo Tsubota,Jun Shimazaki,

OBJECTIVE: To determine the barrier function and cytologic features of ocular surface epithelium after autologous cultivated oral mucosal epithelial transplantation in a prospective observational study. METHODS: The status of the epithelium in 4 eyes with limbal stem cell deficiency was studied preoperatively and postoperatively. We used an impression method to determine the cytologic features and anterior fluorophotometry to determine barrier function. RESULTS: Impression cytology showed nonkeratinized, squamous, polygonal, cohesive cells with a low nuclear to cytoplasmic cell ratio and no goblet cells, corresponding to cultivated oral mucosal epithelium, at up to 16 months after surgery. In some cases, the epithelium displayed a mixture of oral mucosal and conjunctival epithelium, especially in cases with a longer postoperative period. Central epithelial permeability remained persistently high throughout the follow-up period, regardless of the epithelial phenotype. CONCLUSIONS: Cultivated oral mucosal epithelial cells were observed to survive for more than 1 year after transplantation, with gradual replacement by conjunctival epithelium in some cases. Decreased barrier function of the transplanted epithelium may have prognostic implications, suggesting the presence of oral mucosal epithelium long after surgery.

Barrier function and cytologic features of the ocular surface epithelium after autologous cultivated oral mucosal epithelial transplantation. Publishing Authors By Initials

Y Satake,M Dogru,GY Yamane,S Kinoshita,K Tsubota,J Shimazaki,Y Satake,M Dogru,GY Yamane,S Kinoshita,K Tsubota,J Shimazaki,Y Satake,M Dogru,GY Yamane,S Kinoshita,K Tsubota,J Shimazaki,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Barrier function and cytologic features of the ocular surface epithelium after autologous cultivated oral mucosal epithelial transplantation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of ophthalmology

VOLUME: 126

Page Numbers: 23-8

Journal Abbreviation: Arch. Ophthalmol.

ISSN: 0003-9950

DAY: 15

MONTH: Jan

YEAR: 2008

Barrier function and cytologic features of the ocular surface epithelium after autologous cultivated oral mucosal epithelial transplantation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7706534

Barrier function and cytologic features of the ocular surface epithelium after autologous cultivated oral mucosal epithelial transplantation. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Barrier function and cytologic features of the ocular surface epithelium after autologous cultivated oral mucosal epithelial transplantation. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Barrier function and cytologic features of the ocular surface epithelium after autologous cultivated oral mucosal epithelial transplantation.

AFFILIATION: Department of Ophthalmology, Tokyo Dental College, Sugano 5-11-13, Ichikawa, Chiba, 272-8513, Japan. satake@eyebank.or.jp.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Arch Ophthalmol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Barrier function and cytologic features of the ocular surface epithelium after autologous cultivated oral mucosal epithelial transplantation Related Publications

• Achievements and future problems with component surgery of the cornea.
• Amniotic membrane transplantation for wound dehiscence after deep lamellar keratoplasty: a case report.
• Barrier function and cytologic features of the ocular surface epithelium after autologous cultivated oral mucosal epithelial transplantation.
• Blue light-induced autophosphorylation of phototropin is a primary step for signaling.
• Hyperleukocytosis in patients with leukemic follicular lymphoma.
• Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis.
• In vitro effects of bovine lactoferrin on autoaggregation ability and surface hydrophobicity of bifidobacteria.
• Insects from the grazing food web favoured the evolutionary habitat shift to bright environments in araneoid spiders.
• Interrelationship between plasma ionized calcium, plasma noradrenaline (NA) and pressor response to infused NA in patients with essential hypertension.
• Metastasis suppressor genes for prostate cancer.
• Nonsurgical management of patients with blunt hepatic injury: efficacy of transcatheter arterial embolization.
• Nonsurgical management of patients with blunt splenic injury: efficacy of transcatheter arterial embolization.
• Outcome of patients with hormone-refractory prostate cancer: prognostic significance of prostate-specific antigen-doubling time and nadir prostate-specific antigen.
• Physiological properties of projection neurons in the monkey striatum to the globus pallidus.
• Postkeratoplasty atopic sclerokeratitis in keratoconus patients.
• Predicting the severity of systemic inflammatory response syndrome (SIRS)-associated coagulopathy with hemostatic molecular markers and vascular endothelial injury markers.
• Prop-type damping device.
• Protein phosphorylation and binding of a 14-3-3 protein in Vicia guard cells in response to ABA.
• SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia.
• Sensory afferent properties of immobilised or inflamed rat knees during continuous passive movement.
• Thyroid storm after blunt thyroid injury: a case report.
• [A case of caffeine poisoning, survived by percutaneous cardio-pulmonary support]
• [Focal point in the evaluation of nursing fees. A discussion]
• [Multiple coronary aneurysm resulting in myocardial infarction in a young man - successful surgical treatment using a bypass graft]
• [Nursing report: nursing students; attitudes toward nursing at the time of graduation from a 3-year nursing college]
• [Personification; a psychopathological study of the feeling of nature.]
• [Radiation induced osteosarcoma of the chest wall]
• [Simultaneous repair for funnel chest and intracardiac lesions in two pediatric patients]
• [The role of stem cell transplantation for multiple myeloma]
• [Ventricular volume characteristics and function in patients with single ventricle]