Barrett's oesophagus and carcinoma. Recent insights into its development and possible prevention.

Barrett's oesophagus and carcinoma. Recent insights into its development and possible prevention. Research Abstract Details 

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Barrett's oesophagus and carcinoma. Recent insights into its development and possible prevention. Abstract Text:

F T Peters,J H Kleibeuker,

Barrett's oesophagus or columnar epithelium-lined oesophagus is a condition due to chronic gastro-oesophageal reflux. In addition to acid-peptic reflux, reflux of duodenal contents may have a role in its aetiology. The clinical importance of Barrett's oesophagus is the increased risk for development of oesophageal adenocarcinoma. Measures to prevent cancer development have so far been limited to regular screening and early oesophagectomy in the case of severe dysplasia or early cancer. Other modes of intervention, directed toward prevention of dysplasia and possibly regression of Barrett's epithelium, should be sought. Early markers of development toward dysplasia and cancer are necessary if we are to be able to evaluate such measures. Determination of epithelial cell proliferative activity has the potential to be such a marker. A study is now being performed to evaluate the effect of elimination of acid reflux on proliferative activity of Barrett's epithelium in conjunction with the effects of inflammation and development of dysplasia.

Barrett's oesophagus and carcinoma. Recent insights into its development and possible prevention. Publishing Authors By Initials

FT Peters,JH Kleibeuker,

For similar neoplasms: precancerous conditions research abstracts see: neoplasms: precancerous conditions research

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Barrett's oesophagus and carcinoma. Recent insights into its development and possible prevention. Journal Published:

PUBLICATION TYPE: Review

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME: 200

Page Numbers: 59-64

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 1993

Barrett's oesophagus and carcinoma. Recent insights into its development and possible prevention. Information

Number of References: 86

LANGUAGE: eng

NlmUniqueID: 437034

Barrett's oesophagus and carcinoma. Recent insights into its development and possible prevention. Keywords Mesh Terms:

KEYWORDS: Precancerous Conditions

MESH TERMS: complications

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Grant and Affiliation Information for Barrett's oesophagus and carcinoma. Recent insights into its development and possible prevention.

AFFILIATION: Dept. of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands.

Country: NORWAY

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MEDLINETA: Scand J Gastroenterol Suppl

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