Barrett oesophagus and adenocarcinoma: an overview of epidemiologic, conceptual and clinical issues.

Barrett oesophagus and adenocarcinoma: an overview of epidemiologic, conceptual and clinical issues. Research Abstract Details 

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Barrett oesophagus and adenocarcinoma: an overview of epidemiologic, conceptual and clinical issues. Abstract Text:

J W van Sandick,J J van Lanschot,G N Tytgat,G J Offerhaus,H Obertop,

A steady increase in the incidence of adenocarcinoma of the oesophagus and oesophagogastric junction has been observed in Western countries. Patients with distinctive-type Barrett oesophagus are predisposed to developing adenocarcinoma of the oesophagus. Distinctive-type Barrett oesophagus is defined by the presence of intestinal-like goblet cells anywhere in the oesophagus. Adenocarcinomas of the oesophagogastric junction may be associated with short segments of intestinal-type columnar epithelium in the distal oesophagus. Prognosis after surgical resection for cancer of the oesophagus or oesophagogastric junction is strongly affected by the extent of the disease at the time of diagnosis. The identification of Barrett oesophagus as a premalignant condition, the recognition of a stepwise neoplastic progression, along with the poor survival rates of advanced oesophageal adenocarcinoma have initiated the practice of endoscopic biopsy surveillance for patients with Barrett oesophagus. There is supporting evidence that endoscopic biopsy surveillance of Barrett oesophagus permits detection of malignancy at an early stage with favourable results after oesophageal resection. Endoscopic treatment modalities should at this time not be generally adopted in the management of patients with early invasive adenocarcinoma of the oesophagus or oesophagogastric junction.

Barrett oesophagus and adenocarcinoma: an overview of epidemiologic, conceptual and clinical issues. Publishing Authors By Initials

JW van Sandick,JJ van Lanschot,GN Tytgat,GJ Offerhaus,H Obertop,

For similar neoplasms: precancerous conditions research abstracts see: neoplasms: precancerous conditions research

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Barrett oesophagus and adenocarcinoma: an overview of epidemiologic, conceptual and clinical issues. Journal Published:

PUBLICATION TYPE: Review

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME:

Page Numbers: 51-60

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 2001

Barrett oesophagus and adenocarcinoma: an overview of epidemiologic, conceptual and clinical issues. Information

Number of References: 1122

LANGUAGE: eng

NlmUniqueID: 437034

Barrett oesophagus and adenocarcinoma: an overview of epidemiologic, conceptual and clinical issues. Keywords Mesh Terms:

KEYWORDS: Precancerous Conditions

MESH TERMS: epidemiology

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Grant and Affiliation Information for Barrett oesophagus and adenocarcinoma: an overview of epidemiologic, conceptual and clinical issues.

AFFILIATION: Dept. of Surgery, Academic Medical Center, University of Amsterdam, The Netherlands. j.w.vansandick@wanadoo.nl

Country: Norway

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MEDLINETA: Scand J Gastroenterol Suppl

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