Baculovirus-based Vaccination Vectors Allow for Efficient Induction of Immune Responses Against Plasmodium falciparum Circumsporozoite Protein.

Baculovirus-based Vaccination Vectors Allow for Efficient Induction of Immune Responses Against Plasmodium falciparum Circumsporozoite Protein. Research Abstract Details 

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Baculovirus-based Vaccination Vectors Allow for Efficient Induction of Immune Responses Against Plasmodium falciparum Circumsporozoite Protein. Abstract Text:

Robert Strauss,Andreas ,Shaoheng Ni,Sebastian Tuve,Nancy Kiviat,Papa Salif Sow,Christian Hofmann, Lieber,Robert Strauss,Andreas ,Shaoheng Ni,Sebastian Tuve,Nancy Kiviat,Papa Salif Sow,Christian Hofmann, Lieber,

Baculovirus vectors are able to transduce a large variety of mammalian cell types and express transgenes placed under the control of heterologous promoters. In this study, we evaluated the potential of baculovirus vectors for malaria vaccination. To induce efficient CD4(+) and CD8(+) T-cell responses, we produced a series of vectors that display the Plasmodium falciparum circumsporozoite (CS) protein in the virion envelope and/or allow for CS expression upon transduction of mammalian cells. We found that baculovirus vectors can transduce professional antigen-presenting cells and trigger their maturation, which is a prerequisite for efficient antigen presentation. Upon intramuscular injection into mice, the vector that both displayed and expressed CS induced higher anti-CS antibody titers (of the immunoglobulin (IgG)1 and IgG2a type) and a higher frequency of interferon-gamma-producing T cells specific to CS, than the vectors which either only displayed or only expressed CS. The baculovirus CS display/expression vector was also superior in inducing CS-specific CD4(+) and CD8(+) T-cell responses in vitro using human peripheral blood mononuclear cells from naive donors. This, together with the absence of pre-existing immunity to baculoviruses in humans, the absence of viral gene expression in mammalian cells, and the relative low immunogenicity of baculovirus virions, makes these vectors promising tools for vaccination. Furthermore, the ability to produce large amounts in serum-free medium at a low cost adds a further advantage to this vector system.Molecular Therapy (2007) 15, 193-202. doi:10.1038/sj.mt.6300008.

Baculovirus-based Vaccination Vectors Allow for Efficient Induction of Immune Responses Against Plasmodium falciparum Circumsporozoite Protein. Publishing Authors By Initials

R Strauss,A ,S Ni,S Tuve,N Kiviat,PS Sow,C Hofmann,A Lieber,R Strauss,A ,S Ni,S Tuve,N Kiviat,PS Sow,C Hofmann,A Lieber,

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Baculovirus-based Vaccination Vectors Allow for Efficient Induction of Immune Responses Against Plasmodium falciparum Circumsporozoite Protein. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular therapy : the journal of the American So

VOLUME: 15

Page Numbers: 193-202

Journal Abbreviation: Mol. Ther.

ISSN: 1525-0016

DAY: 13

MONTH: Jan

YEAR: 2007

Baculovirus-based Vaccination Vectors Allow for Efficient Induction of Immune Responses Against Plasmodium falciparum Circumsporozoite Protein. Information

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LANGUAGE: eng

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AFFILIATION: 1Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington, USA.

Country: United States

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