Bactericidal activity of OPC-67683 against drug-tolerant Mycobacterium tuberculosis.

Bactericidal activity of OPC-67683 against drug-tolerant Mycobacterium tuberculosis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Bactericidal activity of OPC-67683 against drug-tolerant Mycobacterium tuberculosis. Abstract Text:

Oluwabunmi Y Saliu,Catina Crismale,Stephan K Schwander,Robert S Wallis,Oluwabunmi Y Saliu,Catina Crismale,Stephan K Schwander,Robert S Wallis,Oluwabunmi Y Saliu,Catina Crismale,Stephan K Schwander,Robert S Wallis,

Objectives There is an urgent need for drugs that hasten sterilization in tuberculosis; however, we presently lack indicators of this activity to guide early drug development. We previously described a novel in vitro assay to study mycobacterial phenotypic drug tolerance, in which sterilizing activity could be assessed. OPC-67683 is a novel imidazooxazole that accelerates sterilization in the mouse tuberculosis model. The present study was conducted to determine the activity of OPC-67683 in the in vitro tolerance model using drug-tolerant clinical Mycobacterium tuberculosis strains. Methods Tolerance was assessed in Bactec radiometric culture as: (i) delayed decline in growth index during 14 days of drug exposure; (ii) shorter time to positivity of subcultures following drug exposure. Results Four isolates were selected from among 16 surveyed, based on delayed killing by isoniazid and OPC-67683. Unlike isoniazid and rifampicin, whose rates of killing were concentration-independent, OPC-67683 showed concentration-dependent effects that, at the highest dose levels tested (1.0 microg/mL), were superior to isoniazid and equal to rifampicin. Conclusions The sterilizing activity of OPC-67683 against drug-tolerant M. tuberculosis in the Bactec model is consistent with its activity in mice. Further studies are warranted to examine the effects of OPC-67683 on mycobacterial persistence in tuberculous patients and to determine the biological basis of tolerance in the model.

Bactericidal activity of OPC-67683 against drug-tolerant Mycobacterium tuberculosis. Publishing Authors By Initials

OY Saliu,C Crismale,SK Schwander,RS Wallis,OY Saliu,C Crismale,SK Schwander,RS Wallis,OY Saliu,C Crismale,SK Schwander,RS Wallis,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Bactericidal activity of OPC-67683 against drug-tolerant Mycobacterium tuberculosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of antimicrobial chemotherapy

VOLUME: 60

Page Numbers: 994-8

Journal Abbreviation: J. Antimicrob. Chemother.

ISSN: 0305-7453

DAY: 29

MONTH: 08

YEAR: 2007

Bactericidal activity of OPC-67683 against drug-tolerant Mycobacterium tuberculosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7513617

Bactericidal activity of OPC-67683 against drug-tolerant Mycobacterium tuberculosis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Bactericidal activity of OPC-67683 against drug-tolerant Mycobacterium tuberculosis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Bactericidal activity of OPC-67683 against drug-tolerant Mycobacterium tuberculosis.

AFFILIATION: UMDNJ-New Jersey Medical School, 185 S. Orange Avenue, MSB-185, Newark, NJ, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Antimicrob Chemother

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Bactericidal activity of OPC-67683 against drug-tolerant Mycobacterium tuberculosis Related Publications

• A case of hallucinosis due to cocaine.
• Antiviral activity and molecular features of benzimidazoles.
• Bactericidal activity of OPC-67683 against drug-tolerant Mycobacterium tuberculosis.
• Buoyancy-driven, rapid exhumation of ultrahigh-pressure metamorphosed continental crust.
• Calcium carbonate in the scale from water.
• Cerebral arterial constriction due to contrast media.
• Cervical screening legislation is unethical and has the potential to be counter-productive.
• Clinical trial of trifluoperazine in mental disorders.
• Count on FANYs in an emergency.
• Drawing from the microscope.
• Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator.
• Impact of study design on proarrhythmia prediction in the SCREENIT rabbit isolated heart model.
• Is this disorder for real?
• It started with a kiss (perhaps).
• Leaky answer to greenhouse gas?
• Life sentence.
• Mammalian genome projects reveal new growth hormone (GH) sequences Characterization of the GH-encoding genes of armadillo (Dasypus novemcinctus), hedgehog (Erinaceus europaeus), bat (Myotis lucifugus), hyrax (Procavia capensis), shrew (Sorex araneus), gro
• Mitochondrial phylogeography of New Zealand freshwater crayfishes, Paranephrops spp.
• Orbitofrontal cortex and its contribution to decision-making.
• PAPILLOEDEMA IN RELATION TO GUNSHOT FRACTURE OF THE MANDIBLE.
• Pilot process and outcome evaluation of the introduction of a clinical nutrition pathway in the care of in-hospital renal patients.
• Public health citation patterns: an analysis of the American Journal of Public Health, 2003-2005.
• Re: Lower urinary tract dysfunction in children. What do pre-school teachers know about it?
• Sclerenchyma in the diagnosis and analysis of vegetable powders.
• Synthesis of bis(ethylenedithio)tetrathiafulvalene (BEDT-TTF) derivatives functionalised with two, four or eight hydroxyl groups.
• Taiwanese nurses' attitudes towards and use of complementary and alternative medicine in nursing practice: a cross-sectional survey.
• The British Pharmacopoeia, 1948; crude drugs.
• Transfusion-related acute lung injury (TRALI): presentation, epidemiology and treatment.
• When lead lurks in your nursery.
• [Not Available.]