Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator.

Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator. Abstract Text:

Beth A McCormick,

Bacterial infections at epithelial surfaces, such as those that line the gut and the lung, stimulate the migration of neutrophils through the co-ordinated actions of chemoattractants secreted from pathogen-stimulated epithelial cells. One such factor involved in attracting polymorphonuclear leukocytes across the epithelium and into the lumen has until recently remained elusive. In 2004, we identified the eicosanoid, hepoxilin A(3), to be selectively secreted from the apical surface of human intestinal or lung epithelial cells stimulated with Salmonella enterica serotype Typhimurium or Pseudomonas aeruginosa, respectively. In this role, the function of hepoxilin A(3) is to guide neutrophils, via the establishment of a gradient, across the epithelial tight junction complex. Interestingly, interruption of the synthetic pathway of hepoxilin A(3) blocks the apical release of hepoxilin A(3)in vitro and the transmigration of neutrophils induced by S. typhimurium both in in vitro and in vivo models of inflammation. Such results have led to the discovery of a completely novel pathway that is not only critical for responses to bacterial pathogens but also has broad implications for inflammatory responses affecting mucosal surfaces in general. Thus, the objective of this review was to highlight the recent findings that implicate hepoxilin A(3) as a key regulator of mucosal inflammation.

Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator. Publishing Authors By Initials

BA McCormick,

For similar cells: blood cells: leukocytes: granulocytes: neutrophils research abstracts see: cells: blood cells: leukocytes: granulocytes: neutrophils research

PUBMED ID PMID:

MEDLINE DATE:

Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator. Journal Published:

PUBLICATION TYPE: Review

Journal: The FEBS journal

VOLUME: 274

Page Numbers: 3513-8

Journal Abbreviation: FEBS J.

ISSN: 1742-464X

DAY: 2

MONTH: 07

YEAR: 2007

Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator. Information

Number of References: 31

LANGUAGE: eng

NlmUniqueID: 101229646

Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator. Keywords Mesh Terms:

KEYWORDS: Neutrophils

MESH TERMS: metabolism

Chemical & Substance for Abstract: Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator. Information

Substance Name: 8-hydroxy-11,12-epoxyeicosa-5,9,14-trien

Registry Number: 85589-24-8

Grant and Affiliation Information for Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator.

AFFILIATION: Department of Pediatric Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. mccormic@helix.mgh.harvard.edu

Country: England

AGENCY: United States NIDDK

GRANT: DK56754

ACRONYM: DK

MEDLINETA: FEBS J

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator Related Publications

• A cumulative risk factor model for early identification of academic difficulties in premature and low birth weight infants.
• A distinct mechanism regulating a pollen-specific guanine nucleotide exchange factor for the small GTPase Rop in Arabidopsis thaliana.
• Acrylonitrile; its physiology and toxicology.
• Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways.
• Allergens retained in clothing.
• Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator.
• Characterization of interactions between ras family GTPases and their effectors.
• Colonic device. No. 2,458,719.
• Crystal structure of the streptococcal superantigen SpeI and functional role of a novel loop domain in T cell activation by group V superantigens.
• Decision-making for postpartum discharge of 4300 mothers and their healthy infants: the Life Around Newborn Discharge study.
• Diagnosing cholangiocarcinoma in primary sclerosing cholangitis: an "evidence based radiology" review.
• Efficacy of Experience Sampling and Day Reconstruction Methods as Measures of Physical Activity Intensity: 1330: Board #93 May 30 11:00 AM - 12:30 PM.
• Female and male rats in late adolescence differ from adults in amphetamine-induced locomotor activity, but not in conditioned place preference for amphetamine.
• Fibrous histiocytoma.
• Identification of the Salmonella enterica serotype Typhimurium SipA domain responsible for inducing neutrophil recruitment across the intestinal epithelium.
• Inpatient Hospital Utilization among the Uninsured Near Elderly: Data and Policy Implications for West Virginia.
• Is the Indiana 1935 Sterilization of the Insane Act functioning?
• Ischaemic complications of Glypressin in liver disease: a case series.
• Lessons in applying health impact assessment to regeneration schemes: the Victorian experience.
• Mastectomy With Immediate Expander-Implant Reconstruction, Adjuvant Chemotherapy, and Radiation for Stage II-III Breast Cancer: Treatment Intervals and Clinical Outcomes.
• Molecular basis of TCR selectivity, cross-reactivity, and allelic discrimination by a bacterial superantigen: integrative functional and energetic mapping of the SpeC-Vbeta2.1 molecular interface.
• Patient bypass behavior and critical access hospitals: implications for patient retention.
• Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage.
• Streptomyces coelicolor genes ftsL and divIC play a role in cell division but are dispensable for colony formation.
• Subchronic toxicity and toxicogenomic evaluation of tamoxifen citrate + bexarotene in female rats.
• Subretinal hemorrhage masquerading as a hemorrhagic choroidal detachment in a case of nonaccidental trauma.
• Temperature as a determinant factor for increased and reproducible in vitro pollen germination in Arabidopsis thaliana.
• The Arf GEF GBF1 is required for GGA recruitment to Golgi membranes.
• Things that go 'bump' in the house.
• Type 2 diabetes and tuberculosis in a dynamic bi-national border population.