Bacterial cystitis is accompanied by increased peripheral thermal sensitivity in mice.

Bacterial cystitis is accompanied by increased peripheral thermal sensitivity in mice. Research Abstract Details 

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Bacterial cystitis is accompanied by increased peripheral thermal sensitivity in mice. Abstract Text:

Dale E Bjorling,Zun-Yi Wang,Kyle Boldon,Wade Bushman,Dale E Bjorling,Zun-Yi Wang,Kyle Boldon,Wade Bushman,

PURPOSE: Visceral inflammation and pain associated with chemical cystitis produce increased sensitivity to noxious stimuli in the sacral dermatomes. We determined whether a similar sensitization occurs in response to bacterial cystitis. MATERIALS AND METHODS: Bacterial cystitis was induced by intravesical instillation of Escherichia coli 1677 in female C57BL/6N and C3H/OuJ mice (Jackson Laboratories, Bar Harbor, Maine). C3H/HeJ mice (Jackson Laboratories) served as a control because C3H/HeJ mice lack functional toll-like receptor 4, which is an essential component of cellular recognition of bacterial lipopolysaccharide. Hind paw sensitivity to thermal stimulus was quantitatively determined 1, 2, 7 and 14 days after infection. RESULTS: Intravesical instillation of E. coli produced infection in all strains of mice. Infection persisted in all C3H/OuJ and C3H/HeJ mice but it spontaneously cleared in some C57BL/6N mice. Increased sensitivity to thermal stimuli was observed in C57BL/6N and C3H/OuJ mice starting 1 to 2 days after E. coli instillation and it was still present 14 days after instillation. Increased sensitivity to thermal stimuli did not occur in C3H/HeJ mice. CONCLUSIONS: E. coli induced cystitis produced increased sensitivity to peripheral thermal stimuli in mice with competent toll-like receptor 4.

Bacterial cystitis is accompanied by increased peripheral thermal sensitivity in mice. Publishing Authors By Initials

DE Bjorling,ZY Wang,K Boldon,W Bushman,DE Bjorling,ZY Wang,K Boldon,W Bushman,

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Bacterial cystitis is accompanied by increased peripheral thermal sensitivity in mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of urology

VOLUME: 179

Page Numbers: 759-63

Journal Abbreviation: J. Urol.

ISSN: 1527-3792

DAY: 20

MONTH: 12

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 376374

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Grant and Affiliation Information for Bacterial cystitis is accompanied by increased peripheral thermal sensitivity in mice.

AFFILIATION: Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R01DK57258

ACRONYM: DK

MEDLINETA: J Urol

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