Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus.

Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus. Research Abstract Details 

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Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus. Abstract Text:

Jun Hu,Tom Asbury,Srisairam Achuthan,Conggang Li,Richard Bertram,Jack R Quine,Riqiang Fu,Timothy A Cross,

Amantadine is known to block the M2 proton channel of the Influenza A virus. Here, we present a structure of the M2 trans-membrane domain blocked with amantadine, built using orientational constraints obtained from solid-state NMR polarization-inversion-spin-exchange-at-the-magic-angle experiments. The data indicates a kink in the monomer between two helical fragments having 20 degrees and 31 degrees tilt angles with respect to the membrane normal. This monomer structure is then used to construct a plausible model of the tetrameric amantadine-blocked M2 trans-membrane channel. The influence of amantadine binding through comparative cross polarization magic-angle spinning spectra was also observed. In addition, spectra are shown of the amantadine-resistant mutant, S31N, in the presence and absence of amantadine.

Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus. Publishing Authors By Initials

J Hu,T Asbury,S Achuthan,C Li,R Bertram,JR Quine,R Fu,TA Cross,

For similar proteins: viral proteins: viral structural proteins: viral envelope proteins: viral matrix proteins research abstracts see: proteins: viral proteins: viral structural proteins: viral envelope proteins: viral matrix proteins research

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Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biophysical journal

VOLUME: 92

Page Numbers: 4335-43

Journal Abbreviation: Biophys. J.

ISSN: 0006-3495

DAY: 23

MONTH: 03

YEAR: 2007

Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370626

Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus. Keywords Mesh Terms:

KEYWORDS: Viral Matrix Proteins

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus. Information

Substance Name: Amantadine

Registry Number: 768-94-5

Grant and Affiliation Information for Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus.

AFFILIATION: The National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R01-AI23007

ACRONYM: AI

MEDLINETA: Biophys J

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