B1500, a small membrane protein, connects the two-component systems EvgS/EvgA and PhoQ/PhoP in Escherichia coli.

B1500, a small membrane protein, connects the two-component systems EvgS/EvgA and PhoQ/PhoP in Escherichia coli. Research Abstract Details 

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B1500, a small membrane protein, connects the two-component systems EvgS/EvgA and PhoQ/PhoP in Escherichia coli. Abstract Text:

Yoko Eguchi,Junji Itou,Masatake Yamane,Ryo Demizu,Fumiyuki Yamato,Ario Okada,Hirotada Mori,Akinori Kato,Ryutaro Utsumi,Yoko Eguchi,Junji Itou,Masatake Yamane,Ryo Demizu,Fumiyuki Yamato,Ario Okada,Hirotada Mori,Akinori Kato,Ryutaro Utsumi,

Two-component signal-transduction systems (TCSs) of bacteria are considered to form an intricate signal network to cope with various environmental stresses. One example of such a network in Escherichia coli is the signal transduction cascade from the EvgS/EvgA system to the PhoQ/PhoP system, where activation of the EvgS/EvgA system promotes expression of PhoP-activated genes. As a factor connecting this signal transduction cascade, we have identified a small inner membrane protein (65 aa), B1500. Expression of the b1500 gene is directly regulated by the EvgS/EvgA system, and b1500 expression from a heterologous promoter simultaneously activated the expression of mgtA and other PhoP regulon genes. This activation was PhoQ/PhoP-dependent and EvgS/EvgA-independent. Furthermore, deletion of b1500 from an EvgS-activated strain suppressed mgtA expression. B1500 is localized in the inner membrane, and bacterial two-hybrid data showed that B1500 formed a complex with the sensor PhoQ. These results indicate that the small membrane protein, B1500, connected the signal transduction between EvgS/EvgA and PhoQ/PhoP systems by directly interacting with PhoQ, thus activating the PhoQ/PhoP system.

B1500, a small membrane protein, connects the two-component systems EvgS/EvgA and PhoQ/PhoP in Escherichia coli. Publishing Authors By Initials

Y Eguchi,J Itou,M Yamane,R Demizu,F Yamato,A Okada,H Mori,A Kato,R Utsumi,Y Eguchi,J Itou,M Yamane,R Demizu,F Yamato,A Okada,H Mori,A Kato,R Utsumi,

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B1500, a small membrane protein, connects the two-component systems EvgS/EvgA and PhoQ/PhoP in Escherichia coli. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 18712-7

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 1091-6490

DAY: 12

MONTH: 11

YEAR: 2007

B1500, a small membrane protein, connects the two-component systems EvgS/EvgA and PhoQ/PhoP in Escherichia coli. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

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AFFILIATION: Department of Bioscience, Graduate School of Agriculture, Kinki University, 3327-204, Nakamachi, Nara, 631-8505, Japan.

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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