B lymphocyte deficiency in IgH-transgenic rabbits.

B lymphocyte deficiency in IgH-transgenic rabbits. Research Abstract Details 

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B lymphocyte deficiency in IgH-transgenic rabbits. Abstract Text:

Paul J Jasper,Ki-Jong Rhee,Susan L Kalis,Periannan Sethupathi,Pi-Chen Yam,Shi-Kang Zhai,Katherine L Knight,

We developed IgH-transgenic rabbits carrying a productive VDJ-Cmu Tg and found the rabbits were B cell-deficient, with a 50-100% reduction in serum IgM and IgG levels. The bone marrow of newborn Tg rabbits contained severely reduced levels of preB cells and almost no B cells. The few preB cells present in the bone marrow were large, cycling cells that expressed the VDJ-Cmu Tg, indicating that the block in B cell development likely occurred at or before the transition from large (early) preB to small (late) preB cells. By immunoprecipitation, the Tg mu-chain paired with VpreB and lambda5, suggesting that the B cell deficiency is not due to an inability to form a preB cell receptor. Despite the block in B cell development, a few B cells, expressing predominantly endogenous mu-chains, began the second stage of development in GALT. B cells were localized in and beneath the follicle-associated epithelium of GALT prior to B cell follicle formation, suggesting to us that B cell follicle formation is initiated near the follicle-associated epithelium, possibly through contact with intestinal microbiota. These IgH-Tg rabbits should provide a useful model for studies of B cell development both in bone marrow and in GALT.

B lymphocyte deficiency in IgH-transgenic rabbits. Publishing Authors By Initials

PJ Jasper,KJ Rhee,SL Kalis,P Sethupathi,PC Yam,SK Zhai,KL Knight,

For similar genetic structures: genome: genome components: genes: gene components: exons: vdj exons research abstracts see: genetic structures: genome: genome components: genes: gene components: exons: vdj exons research

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B lymphocyte deficiency in IgH-transgenic rabbits. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: European journal of immunology

VOLUME: 37

Page Numbers: 2290-9

Journal Abbreviation: Eur. J. Immunol.

ISSN: 0014-2980

DAY: 3

MONTH: Aug

YEAR: 2007

B lymphocyte deficiency in IgH-transgenic rabbits. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1273201

B lymphocyte deficiency in IgH-transgenic rabbits. Keywords Mesh Terms:

KEYWORDS: VDJ Exons

MESH TERMS: immunology

Chemical & Substance for Abstract: B lymphocyte deficiency in IgH-transgenic rabbits. Information

Substance Name: Immunoglobulin mu-Chains

Registry Number: 0

Grant and Affiliation Information for B lymphocyte deficiency in IgH-transgenic rabbits.

AFFILIATION: Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL 60153, USA.

Country: Germany

AGENCY: United States NIAID

GRANT: AI 50260

ACRONYM: AI

MEDLINETA: Eur J Immunol

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