B cell depletion in autoimmune rheumatic diseases.

B cell depletion in autoimmune rheumatic diseases. Research Abstract Details 

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B cell depletion in autoimmune rheumatic diseases. Abstract Text:

Milena Pitashny,Yehuda Shoenfeld,

Rituximab is a chimeric mouse-human monoclonal antibody, which binds to CD20, a B cell surface marker, leading to cell death by complement induced lysis and apoptosis. Since the introduction of this drug in the treatment of non-Hodgkin lymphoma, its applications have been extended to autoimmune diseases. This review summarizes the actual possible uses of this novel immune system targeted drug, and explains the mechanism of B cell depletion in autoimmune diseases.

B cell depletion in autoimmune rheumatic diseases. Publishing Authors By Initials

M Pitashny,Y Shoenfeld,

For similar musculoskeletal diseases: rheumatic diseases research abstracts see: musculoskeletal diseases: rheumatic diseases research

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B cell depletion in autoimmune rheumatic diseases. Journal Published:

PUBLICATION TYPE: Review

Journal: Autoimmunity reviews

VOLUME: 4

Page Numbers: 436-41

Journal Abbreviation:

ISSN: 1568-9972

DAY: 1

MONTH: 04

YEAR: 2005

B cell depletion in autoimmune rheumatic diseases. Information

Number of References: 21

LANGUAGE: eng

NlmUniqueID: 101128967

B cell depletion in autoimmune rheumatic diseases. Keywords Mesh Terms:

KEYWORDS: Rheumatic Diseases

MESH TERMS: therapy

Chemical & Substance for Abstract: B cell depletion in autoimmune rheumatic diseases. Information

Substance Name: rituximab

Registry Number: 0

Grant and Affiliation Information for B cell depletion in autoimmune rheumatic diseases.

AFFILIATION: Department of Internal Medicine B and Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel-Hashomer, and Sackler Faculty of Medicine, Tel-Aviv University, Israel.

Country: Netherlands

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MEDLINETA: Autoimmun Rev

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