B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance.

B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance. Research Abstract Details 

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B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance. Abstract Text:

Roland Geisberger,Claudia Kiermayer,Cornelia ,Marcus Conrad, Schmidt,Ursula Zimber-Strobl,Markus Brielmeier,Roland Geisberger,Claudia Kiermayer,Cornelia ,Marcus Conrad, Schmidt,Ursula Zimber-Strobl,Markus Brielmeier,

Thioredoxin reductases (Txnrds) are a group of selenoenzymes participating in cellular redox regulation. Three Txnrd isoforms are known, each of which exhibits distinct cellular localisation and tissue-specific expression pattern. Txnrd1 is found in the cytoplasm, expression of Txnrd2 is restricted to mitochondria and Txnrd3 shows testis-specific expression. Recently, it was shown that Txnrd2 strongly affects the development of blood cells, since mouse embryos deficient for Txnrd2 are severely anaemic, show increased apoptosis in foetal liver and possess haematopoietic liver stem cells of reduced capacity to proliferate in vitro. However, because Txnrd2-deficient mice die at embryonic day 13.5, it was not known how this enzyme affects blood cell function in the adult animal. In the present study we show that conditional Txnrd2 knockouts generated using CD4- and CD19Cre transgenic mice lack Txnrd2 expression in CD4-- and CD19-positive T- and B-lymphocytes, respectively. However, the development and differentiation of both cell types in thymus and bone marrow was not significantly impaired. In addition, B-cell proliferation and activation in response to CD40 and IL-4 was unaltered in Txnrd2-deficient B-cells.

B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance. Publishing Authors By Initials

R Geisberger,C Kiermayer,C ,M Conrad,J Schmidt,U Zimber-Strobl,M Brielmeier,R Geisberger,C Kiermayer,C ,M Conrad,J Schmidt,U Zimber-Strobl,M Brielmeier,

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B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological chemistry

VOLUME: 388

Page Numbers: 1083-90

Journal Abbreviation: Biol. Chem.

ISSN: 1431-6730

DAY: 16

MONTH: Oct

YEAR: 2007

B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance. Information

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LANGUAGE: eng

NlmUniqueID: 9700112

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AFFILIATION: Department of Comparative Medicine, GSF Research Centre for Environment and Health, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany. roland@mrc-lmb.cam.ac.uk

Country: Germany

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MEDLINETA: Biol Chem

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