Axon & dendrite degeneration: Its mechanisms and protective experimental paradigms.

Axon & dendrite degeneration: Its mechanisms and protective experimental paradigms. Research Abstract Details 

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Axon & dendrite degeneration: Its mechanisms and protective experimental paradigms. Abstract Text:

Tatsuro Koike,Yi Yang,Kazuhiko Suzuki,Xiaoxiang Zheng,

Accumulating evidence suggests that axon and dendrite (or neurite) degeneration both in vivo and in vitro requires self-destructive programs independent of cell death programs to segregate neurite degeneration from cell soma demise. This review will deal with the mechanisms of neurite degeneration caused by several experimental paradigms including trophic factor deprivation and Wallerian degeneration as well as those under pathological conditions. The involvement of autophagy and mitochondrial dysfunction is emphasized in these mechanisms. The mechanisms through which protective agents including the Wld(s) protein rescue neurites from degeneration or fail to do so will be discussed.

Axon & dendrite degeneration: Its mechanisms and protective experimental paradigms. Publishing Authors By Initials

T Koike,Y Yang,K Suzuki,X Zheng,

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MEDLINE DATE: 2008 Mar-Apr

Axon & dendrite degeneration: Its mechanisms and protective experimental paradigms. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neurochemistry international

VOLUME: 52

Page Numbers: 751-60

Journal Abbreviation: Neurochem. Int.

ISSN: 0197-0186

DAY: 16

MONTH: 09

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 8006959

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Grant and Affiliation Information for Axon & dendrite degeneration: Its mechanisms and protective experimental paradigms.

AFFILIATION: Molecular Neurobiology Laboratory, Division of Life Science, Graduate School of Life Science, Hokkaido University, North Ward N10 W8, Sapporo 060-0810, Japan.

Country: England

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MEDLINETA: Neurochem Int

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