Axial patterning in the developing vertebrate inner ear.

Axial patterning in the developing vertebrate inner ear. Research Abstract Details 

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Axial patterning in the developing vertebrate inner ear. Abstract Text:

Tanya T Whitfield,Katherine L Hammond,Tanya T Whitfield,Katherine L Hammond,

Axial patterning in the vertebrate inner ear has been studied for over eighty years, and recent work has made great progress towards an understanding of the molecular mechanisms responsible for establishing asymmetries about the otic axes. Tissues extrinsic to the ear provide sources of signalling molecules that are active early in development, at or before otic placode stages, while intrinsic factors interpret these signals to establish and maintain axial pattern. Key features of dorsoventral otic patterning in amniote embryos involve Wnt and Fgf signalling from the hindbrain and Hh signalling from midline tissues (notochord and floorplate). Mutual antagonism between these pathways and their downstream targets within the otic epithelium help to refine and maintain dorsoventral axial patterning in the ear. In the zebrafish ear, the same tissues and signals are implicated, but appear to play a role in anteroposterior, rather than dorsoventral, otic patterning. Despite this paradox, conservation of mechanisms may be higher than is at first apparent.

Axial patterning in the developing vertebrate inner ear. Publishing Authors By Initials

TT Whitfield,KL Hammond,TT Whitfield,KL Hammond,

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Axial patterning in the developing vertebrate inner ear. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The International journal of developmental biology

VOLUME: 51

Page Numbers: 507-20

Journal Abbreviation: Int. J. Dev. Biol.

ISSN: 0214-6282

DAY: 24

MONTH: 09

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 8917470

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AFFILIATION: Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, UK. t.whitfield@sheffield.ac.uk

Country: Spain

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MEDLINETA: Int J Dev Biol

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