Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct.

Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct. Research Abstract Details 

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Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct. Abstract Text:

Monica Carmosino,Heddwen L Brooks,Qi Cai,Linda S Davis,Susan Opalenik,Chuanming Hao,Matthew D Breyer,

Vasopressin and vasopressin antagonists are finding expanded use in mouse models of disease and in clinical medicine. To provide further insight into the physiological role of V1a and V2 vasopressin receptors in the human and mouse kidney, intrarenal localization of the receptors mRNA was determined by in situ hybridization. V2-receptor mRNA was predominantly expressed in the medulla, whereas mRNA for V1a receptors predominated in the cortex. The segmental localization of vasopressin-receptor mRNAs was determined using simultaneous in situ hybridization and immunohistochemistry for segment-specific markers, including aquaporin-2, Dolichos biflorus agglutinin, epithelial Na channels, Tamm Horsfall glycoprotein, and thiazide-sensitive Na(+)-Cl(-) cotransporter. Notably, V1a receptor expression was exclusively expressed in V-ATPase/anion exchanger-1-labeled alpha-intercalated cells of the medullary collecting duct in both mouse and human kidney. In cortical collecting ducts, V1a mRNA was more widespread and detected in both principal and intercalated cells. V2-receptor mRNA is diffusely expressed along the collecting ducts in both mouse and human kidney, with higher expression levels in the medulla. These results demonstrate heterogenous axial expression of both V1a and V2 vasopressin receptors along the human and mouse collecting duct. The restricted expression of V1a-receptor mRNA in intercalated cells suggests a role for this receptor in acid-base balance. These findings further suggest distinct regulation of renal transport function by AVP through V1a and V2 receptors in the cortex vs. the medulla.

Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct. Publishing Authors By Initials

M Carmosino,HL Brooks,Q Cai,LS Davis,S Opalenik,C Hao,MD Breyer,

For similar investigative techniques: clinical laboratory techniques: cytological techniques: histocytological preparation techniques: tissue embedding research abstracts see: investigative techniques: clinical laboratory techniques: cytological techniques: histocytological preparation techniques: tissue embedding research

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Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of physiology. Renal physiology

VOLUME: 292

Page Numbers: F351-60

Journal Abbreviation: Am. J. Physiol. Renal Physiol.

ISSN: 0363-6127

DAY: 11

MONTH: 07

YEAR: 2006

Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901990

Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct. Keywords Mesh Terms:

KEYWORDS: Tissue Embedding

MESH TERMS: metabolism

Chemical & Substance for Abstract: Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct. Information

Substance Name: Receptors, Vasopressin

Registry Number: 0

Grant and Affiliation Information for Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct.

AFFILIATION: Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK-37097

ACRONYM: DK

MEDLINETA: Am J Physiol Renal Physiol

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