Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine.

Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine. Research Abstract Details 

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Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine. Abstract Text:

Dao-Yao He,Dorit Ron,

We recently showed that the up-regulation of the glial cell line-derived neurotrophic factor (GDNF) pathway in the midbrain, is the molecular mechanism by which the putative anti-addiction drug Ibogaine mediates its desirable action of reducing alcohol consumption. Human reports and studies in rodents have shown that a single administration of Ibogaine results in a long-lasting reduction of drug craving (humans) and drug and alcohol intake (rodents). Here we determine whether, and how, Ibogaine exerts its long-lasting actions on GDNF expression and signaling. Using the dopaminergic-like SHSY5Y cell line as a culture model, we observed that short-term Ibogaine exposure results in a sustained increase in GDNF expression that is mediated via the induction of a long-lasting autoregulatory cycle by which GDNF positively regulates its own expression. We show that the initial exposure of cells to Ibogaine or GDNF results in an increase in GDNF mRNA, leading to protein expression and to the corresponding activation of the GDNF signaling pathway. This, in turn, leads to a further increase in the mRNA level of the growth factor. The identification of a GDNF-mediated, autoregulatory long-lasting feedback loop could have important implications for GDNF's potential value as a treatment for addiction and neurodegenerative diseases.

Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine. Publishing Authors By Initials

DY He,D Ron,

For similar nervous system: neuroglia research abstracts see: nervous system: neuroglia research

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Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The FASEB journal : official publication of the Fe

VOLUME: 20

Page Numbers: 2420-2

Journal Abbreviation: FASEB J.

ISSN: 1530-6860

DAY: 3

MONTH: 10

YEAR: 2006

Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine. Information

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LANGUAGE: eng

NlmUniqueID: 8804484

Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine. Keywords Mesh Terms:

KEYWORDS: Neuroglia

MESH TERMS: physiology

Chemical & Substance for Abstract: Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine. Information

Substance Name: Ibogaine

Registry Number: 83-74-9

Grant and Affiliation Information for Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine.

AFFILIATION: Ernest Gallo Research Center, Emeryville, California, USA.

Country: United States

AGENCY: United States NIAAA

GRANT: 5 R01 AA014366–02

ACRONYM: AA

MEDLINETA: FASEB J

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