Autoregulation of cerebral blood flow in fetuses with congenital heart disease: the brain sparing effect.

Autoregulation of cerebral blood flow in fetuses with congenital heart disease: the brain sparing effect. Research Abstract Details 

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Autoregulation of cerebral blood flow in fetuses with congenital heart disease: the brain sparing effect. Abstract Text:

M T Donofrio,Y A Bremer,R M Schieken,C Gennings,L D Morton,B W Eidem,F Cetta,C B Falkensammer,J C Huhta,C S Kleinman,

Fetuses with congenital heart disease (CHD) have circulatory abnormalities that may compromise cerebral oxygen delivery. We believe that some CHD fetuses with decreased cerebral oxygen supply have autoregulation of blood flow that enhances cerebral perfusion (brain sparing). We hypothesize that cerebral autoregulation occurs in CHD fetuses, and the degree of autoregulation is dependent on the specific CHD and correlates with intrauterine head circumferences. CHD fetuses were compared to normal fetuses. Data included cardiac diagnosis, cerebral and umbilical artery Doppler, head circumference, weight, and gestational age. The cerebral-to-placental resistance ratio (CPR) was assessed as a measure of cerebral autoregulation. CPR = cerebral/umbilical resistance index (RI) and RI = systolic-diastolic/systolic velocity (normal CPR > 1). CPR > 1 was found in 95% of normal vs 44% of CHD fetuses. The incidence of CPR < 1 was greatest in hypoplastic left or right heart fetuses. Compared to normal, cerebral RI was decreased in CHD fetuses. The CPR vs gestational age relationship, and the relationship among weight, head circumference, and CPR differed across normal and CHD fetuses. Fetuses > 2 kg with CHD and a CPR < 1 had smaller head circumferences than normal. Brain sparing occurs in CHD fetuses. Fetuses with single ventricular physiology are most affected. Inadequate cerebral flow in CHD fetuses, despite autoregulation, may alter brain growth.

Autoregulation of cerebral blood flow in fetuses with congenital heart disease: the brain sparing effect. Publishing Authors By Initials

MT Donofrio,YA Bremer,RM Schieken,C Gennings,LD Morton,BW Eidem,F Cetta,CB Falkensammer,JC Huhta,CS Kleinman,

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research

PUBMED ID PMID:

MEDLINE DATE: 2003 Sep-Oct

Autoregulation of cerebral blood flow in fetuses with congenital heart disease: the brain sparing effect. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatric cardiology

VOLUME: 24

Page Numbers: 436-43

Journal Abbreviation: Pediatr Cardiol

ISSN: 0172-0643

DAY: 20

MONTH: 02

YEAR: 2008

Autoregulation of cerebral blood flow in fetuses with congenital heart disease: the brain sparing effect. Information

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LANGUAGE: eng

NlmUniqueID: 8003849

Autoregulation of cerebral blood flow in fetuses with congenital heart disease: the brain sparing effect. Keywords Mesh Terms:

KEYWORDS: Prospective Studies

MESH TERMS: embryology

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Grant and Affiliation Information for Autoregulation of cerebral blood flow in fetuses with congenital heart disease: the brain sparing effect.

AFFILIATION: Medical College of Virginia, Hospital of the Virginia Commonwealth University, Box 980342, Richmond, VA 23298, USA.

Country: United States

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MEDLINETA: Pediatr Cardiol

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