Autoreactive B-1 B cells: Constraints on natural autoantibody B cell antigen receptors.

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Autoreactive B-1 B cells: Constraints on natural autoantibody B cell antigen receptors. Abstract Text:

Ben Rowley,Lingjuan Tang,Susan Shinton,Kyoko Hayakawa,Richard R Hardy,Ben Rowley,Lingjuan Tang,Susan Shinton,Kyoko Hayakawa,Richard R Hardy,Ben Rowley,Lingjuan Tang,Susan Shinton,Kyoko Hayakawa,Richard R Hardy,

B-1 B-cells constitute a distinctive population of cells that are enriched for self-reactive B cell receptors (BCRs). These BCRs are encoded by a restricted set of heavy and light chains, including heavy chains that lack nontemplated nucleotide additions at the V-D and D-J joining regions. One prototype natural autoantibody produced by B-1 B cells binds to a cryptic determinant exposed on senescent red blood cells that includes the phosphatidylcholine (PtC) moiety. The V(H)11Vkappa9 BCR, which accounts for a large fraction of the anti-PtC specificity, is underrepresented in other B-cell populations, including newly formed B cells in bone marrow, and the transitional B cells, follicular B cells, and marginal zone B cells in spleen. Previous work has shown that V(H)11 heavy chains pair ineffectively with surrogate light chain (SLC) and so do not promote development in bone marrow, but instead allow fetal liver maturation because of a fetal preference for weaker pre-BCR signaling. Such inefficient SLC pairing constitutes one constraint on the maturation of B cells containing V(H)11 rearrangements that biases their generation to fetal development. Here, we examine another possible bottleneck to the B1 cell repertoire: light chain pairing with V(H)11 heavy chain, finding very significant preferences.

Autoreactive B-1 B cells: Constraints on natural autoantibody B cell antigen receptors. Publishing Authors By Initials

B Rowley,L Tang,S Shinton,K Hayakawa,RR Hardy,B Rowley,L Tang,S Shinton,K Hayakawa,RR Hardy,B Rowley,L Tang,S Shinton,K Hayakawa,RR Hardy,

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Autoreactive B-1 B cells: Constraints on natural autoantibody B cell antigen receptors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of autoimmunity

VOLUME: 29

Page Numbers: 236-45

Journal Abbreviation: J. Autoimmun.

ISSN: 0896-8411

DAY: 21

MONTH: 09

YEAR: 2007

Autoreactive B-1 B cells: Constraints on natural autoantibody B cell antigen receptors. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Autoreactive B-1 B cells: Constraints on natural autoantibody B cell antigen receptors.

AFFILIATION: Division of Basic Science, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA.

Country: England

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MEDLINETA: J Autoimmun

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