Autophagy-related genes from a tick, Haemaphysalis longicornis.

Autophagy-related genes from a tick, Haemaphysalis longicornis. Research Abstract Details 

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Autophagy-related genes from a tick, Haemaphysalis longicornis. Abstract Text:

Rika Umemiya,Tomohide Matsuo,Takeshi Hatta,Shin-Ichi Sakakibara,Damdinsuren Boldbaatar,Kozo Fujisaki,

Ticks are gorging-fasting organisms;(1) their life cycle is characterized by alternate off-host (starvation) and on-host (meal) conditions. Their generation time is estimated in several years and many ticks spend more than 95% of their life off the host. They seem to have a unique strategy to endure the off-host state for a long period. Thus, we focused on autophagy, which is induced by starvation and is essential for extension of the lifespan,(2-4) and hypothesized that ticks also have a system of autophagy to overcome the starved condition. Recently, we showed the existence of a homologue of an ATG gene, ATG12, and its expression pattern from nymphal to adult stages in a three-host tick, Haemaphysalis longicornis. The expression level of HlATG12 was downregulated at the beginning of feeding and was highest at 3 months after engorgement. In addition, the HlAtg12 protein was localized to the region around granule-like structures within midgut cells of unfed adults. These results indicate that HlATG12 functions during unfed stages. Here, a potential role of autophagy in unfed ticks is discussed with regard to reports in other animals, such as yeast, mammal, and fruit fly.

Autophagy-related genes from a tick, Haemaphysalis longicornis. Publishing Authors By Initials

R Umemiya,T Matsuo,T Hatta,S Sakakibara,D Boldbaatar,K Fujisaki,

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Autophagy-related genes from a tick, Haemaphysalis longicornis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Autophagy

VOLUME: 4

Page Numbers: 79-81

Journal Abbreviation: Autophagy

ISSN: 1554-8635

DAY: 9

MONTH: 10

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 101265188

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AFFILIATION: Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan.

Country: United States

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MEDLINETA: Autophagy

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