Autophagy gene-dependent clearance of apoptotic cells during embryonic development.

Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Research Abstract Details 

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Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Abstract Text:

Autophagy is commonly observed in metazoan organisms during programmed cell death (PCD), but its function in dying cells has been unclear. We studied the role of autophagy in embryonic cavitation, the earliest PCD process in mammalian development. Embryoid bodies (EBs) derived from cells lacking the autophagy genes, atg5 or beclin 1, fail to cavitate. This defect is due to persistence of cell corpses, rather than impairment of PCD. Dying cells in autophagy gene null EBs fail to express the "eat-me" signal, phosphatidylserine exposure, and secrete lower levels of the "come-get-me" signal, lysophosphatidylcholine. These defects are associated with low levels of cellular ATP and are reversed by treatment with the metabolic substrate, methylpyruvate. Moreover, mice lacking atg5 display a defect in apoptotic corpse engulfment during embryonic development. We conclude that autophagy contributes to dead-cell clearance during PCD by a mechanism that likely involves the generation of energy-dependent engulfment signals.

Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Publishing Authors By Initials

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell

VOLUME: 128

Page Numbers: 931-46

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 9

MONTH: Mar

YEAR: 2007

Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413066

Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: cytology

Chemical & Substance for Abstract: Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Information

Substance Name: Adenosine Triphosphate

Registry Number: 56-65-5

Grant and Affiliation Information for Autophagy gene-dependent clearance of apoptotic cells during embryonic development.

AFFILIATION: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA 084254

ACRONYM: CA

MEDLINETA: Cell

REFSOURCE: Cell. 2007 Mar 9;128(5):833-6

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