Autophagy and human disease.

Autophagy and human disease. Research Abstract Details 

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Autophagy and human disease. Abstract Text:

Ju Huang,Daniel J Klionsky,

As a conserved cellular degradative pathway in eukaryotes, autophagy relieves cells from various types of stress. There are different forms of autophagy, and the ongoing studies of the molecular mechanisms and cellular functions of these processes are unraveling their significant roles in human health. Currently, the best-studied of these pathways is macroautophagy, which is linked to a range of human disease. For example, as part of the host immune defense mechanism, macroautophagy is activated to eliminate invasive pathogenic bacteria; however, in some cases bacteria subvert this process for their own replication. Autophagy also contributes to endogenous major histocompatibility complex class II antigen presentation, reflecting its role in adaptive immunity. In certain neurodegenerative diseases, which are associated with aggregation-prone proteins, macroautophagy plays a protective role in preventing or reducing cytotoxicity by clearance of the toxic proteins; however, the autophagy-dependent processing of some components correlates with the pathogenesis of certain myopathies. Finally, autophagy acts as a mechanism for tumor suppression, although some cancer cells use it as a cytoprotective mechanism. Thus, a fundamental paradox of autophagy is that it can act to promote both cell survival and cell death, depending on the specific conditions.

Autophagy and human disease. Publishing Authors By Initials

J Huang,DJ Klionsky,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Autophagy and human disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Cell cycle (Georgetown, Tex.)

VOLUME: 6

Page Numbers: 1837-49

Journal Abbreviation: Cell Cycle

ISSN: 1551-4005

DAY: 25

MONTH: 05

YEAR: 2007

Autophagy and human disease. Information

Number of References: 123

LANGUAGE: eng

NlmUniqueID: 101137841

Autophagy and human disease. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: pathology

Chemical & Substance for Abstract: Autophagy and human disease. Information

Substance Name: Antigens

Registry Number: 0

Grant and Affiliation Information for Autophagy and human disease.

AFFILIATION: University of Michigan, Life Sciences Institute, Department of Molecular, Cellular and Developmental Biology, Ann Arbor, Michigan 48109 , USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM53396

ACRONYM: GM

MEDLINETA: Cell Cycle

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