Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists.

Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists. Abstract Text:

B F Cox,R L Schelper,F M Faraci,M J Brody,

Antagonists of the putative peptide neurotransmitter substance P have been found to produce pronounced cardiovascular effects when administered into the spinal subarachnoid space. These previous studies have not, however, provided any direct evidence that these effects result from interaction with substance P receptors. The present study was designed to characterize the modification of cardiovascular function resulting from administration of these compounds, and evaluate their effects on the integrity of spinal cord function. Intrathecal administration of two substance P antagonists produced a depressor response accompanied by a reduction of hindquarter vascular resistance. Following administration of a substance P antagonist, the integrated cardiovascular responses to electrical stimulation of the renal afferent nerves and ventrolateral medulla were markedly attenuated. Intrathecal administration to conscious rats of three substance P antagonists led to a variety of sensory and motor dysfunctions, including loss of spontaneous motor function, responsiveness to mechanical and thermal stimuli, and bladder function. No such effects were produced by administration of substance P, luteinizing hormone releasing hormone (LHRH), or LHRH antagonist. These effects from administration of a substance P antagonist were associated with a dose-dependent necrosis of spinal cord tissue. The necrosis may be secondary to ischemia since pretreatment with the vasodilator adenosine significantly delayed or blocked the sensory and motor dysfunctions. This conclusion was supported by the demonstration that cerebrovascular smooth muscle (pial vessels) was constricted by a SP antagonist. Taken together, these data suggest that substance P antagonists appear to non-specifically block transmission in the spinal cord, by mechanisms which may involve reduction of blood flow to the spinal cord.

Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists. Publishing Authors By Initials

BF Cox,RL Schelper,FM Faraci,MJ Brody,

For similar peptides: intercellular signaling peptides and proteins: kinins: tachykinins: substance p research abstracts see: peptides: intercellular signaling peptides and proteins: kinins: tachykinins: substance p research

PUBMED ID PMID:

MEDLINE DATE:

Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 70

Page Numbers: 61-72

Journal Abbreviation:

ISSN: 0014-4819

DAY: 15

MONTH: 02

YEAR: 1988

Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 43312

Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists. Keywords Mesh Terms:

KEYWORDS: Substance P

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists. Information

Substance Name: substance P, Arg(1)-Pro(2)-Trp(7,9)-Leu(

Registry Number: 83374-71-4

Grant and Affiliation Information for Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists.

AFFILIATION: Department of Pharmacology, College of Medicine, University of Iowa, Iowa City 52242.

Country: GERMANY, WEST

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Exp Brain Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists Related Publications

• A New Method of Selecting Health Officers-in-Training.
• A case of complete heart block reverting to normal sinus rhythm after treatment for cardiac invasive Burkitt's lymphoma.
• Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer.
• Cancer risk among Los Angeles women with cosmetic breast implants.
• Delays and errors in the diagnosis of brain tumor.
• Depression, functional status, treatment for psychiatric problems, and the health-related practices of elderly HMO members.
• Design of continuous attractor networks with monotonic tuning using a symmetry principle.
• Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury.
• Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury.
• Dynamic SPR monitoring of yeast nuclear protein binding to a cis-regulatory element.
• Early experience with racial discrimination and conduct disorder as predictors of subsequent drug use: a critical period hypothesis.
• Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis.
• Ethical issues in adolescent and parent informed consent for pediatric asthma research participation.
• Finding family for prospective consent in emergency research.
• Frontal lobotomy; clinical experience with 107 cases in a state hospital.
• Immunoassay of gonadotrophins using complement fixation.
• Laparoscopic resection of an adrenal pseudocyst.
• Management and therapy for sports hernia.
• Manning the battlements of research epidemiology.
• Measurement-Dependent Filtering: A Novel Approach to Improved SNR.
• Microsensor arrays for saliva diagnostics.
• Mutualism as reciprocal exploitation: African plant-ants defend foliar but not reproductive structures.
• PHOSPHORYLASE ACTIVITY IN RAT LIVER AND SKELETAL MUSCLE AFTER CATECHOLAMINES.
• Point: genetic risk feedback for common disease time to test the waters.
• Psychologic tension and serum iodine levels in psychiatric patients without evidence of thyroid disease.
• Scleroma; review of literature and first report of multiple familial occurrence in the United States.
• Self-control, symptomatology, and substance use precursors: test of a theoretical model in a community sample of 9-year-old children.
• Shock after administration of prochlorperazine in patient with pheochromocytoma; report of a case with spontaneous tumor destruction.
• Short-term naturalistic treatment outcomes in cigarette smokers with substance abuse and/or mental illness.
• The use of the male leopard frog (Rana pipiens) as a pregnancy test animal.