Autonomic reactivity to induced emotion as potential predictor of response to antidepressant treatment.

Autonomic reactivity to induced emotion as potential predictor of response to antidepressant treatment. Research Abstract Details 

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Autonomic reactivity to induced emotion as potential predictor of response to antidepressant treatment. Abstract Text:

Renerio Fraguas,Carl Marci,Maurizio Fava,Dan V Iosifescu,Bettina Bankier,Rebecca Loh,Darin D Dougherty,

Distinct factors have been identified as potential predictors of antidepressant treatment response. Although autonomic function changes have been described in depressive subjects, their value as predictors of antidepressant response has not been systematically evaluated. Eight un-medicated patients with major depressive order (MDD) have their skin conductance (SC) and heart rate variability (HRV) measured at basal condition and during four induced emotional states: happy, angry, sad and neutral. The high frequency (HF) and low frequency (LF) power parameters of HRV were assessed. Subsequently, patients were treated with fluoxetine 20 mg/day for 8 weeks. The antidepressant response was measured with the Beck Depression Inventory (BDI). The BDI percentage reduction correlated significantly with HRV responses during sad condition in LF power, and during happy condition with LF/HF ratio. The BDI percentage reduction also correlated significantly with HR responses in happy and in neutral conditions, and also with SC responses in neutral condition. These preliminary findings indicate that automatic responses to induced emotions may predict antidepressant response in MDD patients. Confirmatory studies are warranted.

Autonomic reactivity to induced emotion as potential predictor of response to antidepressant treatment. Publishing Authors By Initials

R Fraguas,C Marci,M Fava,DV Iosifescu,B Bankier,R Loh,DD Dougherty,

For similar chemical actions and uses: pharmacologic actions: molecular mechanisms of pharmacological action: neurotransmitter agents: neurotransmitter uptake inhibitors: serotonin uptake inhibitors research abstracts see: chemical actions and uses: pharmacologic actions: molecular mechanisms of pharmacological action: neurotransmitter agents: neurotransmitter uptake inhibitors: serotonin uptake inhibitors research

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MEDLINE DATE:

Autonomic reactivity to induced emotion as potential predictor of response to antidepressant treatment. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Psychiatry research

VOLUME: 151

Page Numbers: 169-72

Journal Abbreviation:

ISSN: 0165-1781

DAY: 13

MONTH: 03

YEAR: 2007

Autonomic reactivity to induced emotion as potential predictor of response to antidepressant treatment. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7911385

Autonomic reactivity to induced emotion as potential predictor of response to antidepressant treatment. Keywords Mesh Terms:

KEYWORDS: Serotonin Uptake Inhibitors

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Autonomic reactivity to induced emotion as potential predictor of response to antidepressant treatment. Information

Substance Name: Fluoxetine

Registry Number: 54910-89-3

Grant and Affiliation Information for Autonomic reactivity to induced emotion as potential predictor of response to antidepressant treatment.

AFFILIATION: Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. rfaguas@partners.org

Country: Ireland

AGENCY: United States NIMH

GRANT: MH017350

ACRONYM: MH

MEDLINETA: Psychiatry Res

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