Autonomic nerve stimulation reverses ventricular repolarization sequence in rabbit hearts.

Autonomic nerve stimulation reverses ventricular repolarization sequence in rabbit hearts. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Autonomic nerve stimulation reverses ventricular repolarization sequence in rabbit hearts. Abstract Text:

Rajkumar Mantravadi,Bethann Gabris,Tong Liu,Bum-Rak Choi,William C de Groat, Ng,Guy Salama,

Sympathetic activity and spatial dispersion of repolarization (DOR) have been implicated as mechanisms that promote arrhythmia vulnerability; yet there are no direct measurements of the effects of autonomic nerve stimulation on DOR. Rabbit hearts were perfused in a Langendorff apparatus with full sympathetic and parasympathetic innervation and were optically mapped to measure action potential durations and DOR (apex-base) over the left ventricles. DOR was measured under sinus rhythm, during bilateral sympathetic nerve stimulation (SNS) and right and/or left vagus nerve stimulation and was compared with DOR during isoproterenol (100 nmol/L) or acetylcholine (1 micromol/L) infusion. In sinus rhythm, repolarization started at the apex and systematically progressed toward the base. SNS (10 to 15 Hz) increased DOR by 29% (from Deltaaction potential duration=17+/-0.7 to -22+/-1.6 ms, n=6) and reversed DOR as the direction of repolarization from apex-->base in sinus rhythm shifted to base-->apex in 5 to 15 seconds after SNS. DOR flipped back to its sinus rhythm DOR pattern 115+/-15 seconds after the interruption of SNS. During right or left vagus nerve stimulation, there was no change in the direction of DOR, but bilateral vagus nerve stimulation increased and reversed DOR to base-->apex direction. Infusion of isoproterenol or acetylcholine increased DOR but did not alter the direction of repolarization sequences. These findings demonstrate that bilateral autonomic activity (SNS or vagus nerve stimulation) cause reversible shifts of apex-base DOR and that the spatial heterogeneities of autonomic effects on the ventricles are most likely attributable to a greater innervation at the base than the apex of the heart.

Autonomic nerve stimulation reverses ventricular repolarization sequence in rabbit hearts. Publishing Authors By Initials

R Mantravadi,B Gabris,T Liu,BR Choi,WC de Groat,GA Ng,G Salama,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: ventricular function research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: ventricular function research

PUBMED ID PMID:

MEDLINE DATE:

Autonomic nerve stimulation reverses ventricular repolarization sequence in rabbit hearts. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Circulation research

VOLUME: 100

Page Numbers: e72-80

Journal Abbreviation:

ISSN: 1524-4571

DAY: 15

MONTH: 03

YEAR: 2007

Autonomic nerve stimulation reverses ventricular repolarization sequence in rabbit hearts. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 47103

Autonomic nerve stimulation reverses ventricular repolarization sequence in rabbit hearts. Keywords Mesh Terms:

KEYWORDS: Ventricular Function

MESH TERMS: drug effects

Chemical & Substance for Abstract: Autonomic nerve stimulation reverses ventricular repolarization sequence in rabbit hearts. Information

Substance Name: Isoproterenol

Registry Number: 7683-59-2

Grant and Affiliation Information for Autonomic nerve stimulation reverses ventricular repolarization sequence in rabbit hearts.

AFFILIATION: Department of Cardiovascular Sciences, Cardiology Group, University of Leicester, UK.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL70722

ACRONYM: HL

MEDLINETA: Circ Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Autonomic nerve stimulation reverses ventricular repolarization sequence in rabbit hearts Related Publications

• A highly sensitive particle agglutination assay for the detection of P53 autoantibodies in patients with lung cancer.
• A rapid gel agglutination test for the determination of fetomaternal haemorrhage.
• Application of the particle gel agglutination assay in the typing of single human leucocyte antigens.
• Application of the particle gel agglutination system as a new check gel assay for PCR products.
• Association between alloantibody specificity and autoantibodies to red blood cells.
• Autoimmune thrombocytopenia in two patients with Sneddon's Syndrome.
• Autonomic nerve stimulation reverses ventricular repolarization sequence in rabbit hearts.
• Calcium transients modulate action potential repolarizations in ventricular fibrillation.
• Design optimization methodology for dry EEG spikes array electrode.
• Dreams and dreaming. Part one.
• Dreams and dreaming. Part two.
• Dual-dye optical mapping after myocardial infarction: does the site of ventricular stimulation alter the properties of electrical propagation?
• Effects of marjoram volatile oil and grape seed extract on ethanol toxicity in male rats.
• Enhanced aqueous solubility of long wavelength voltage-sensitive dyes by covalent attachment of polyethylene glycol.
• Hughes-Stovin syndrome: is it incomplete Behçet's? Report of two cases and review of the literature.
• Identification of Helicobacter pylori genes that contribute to stomach colonization.
• Identification of a novel HLA-DQB1 allele, HLA-DQB1*0632.
• Immune tolerance induction in patients with IgA anaphylactoid reactions following long-term intravenous IgG treatment.
• Iridoid Glucosides from Euphrasia rostkoviana.
• Monte Carlo Simulation of 3D Mapping of Cardiac Electrical Activity with Spinning Slit Confocal Optics.
• Occurrence and overlap of natural disasters, complex emergencies and epidemics during the past decade (1995-2004).
• Optimum storage conditions for cord blood-derived hematopoietic progenitor cells prior to isolation.
• Production of proinflammatory cytokines: granulocyte-macrophage colony stimulating factor, interleukin-8 and interleukin-6 by peripheral blood mononuclear cells of protein energy malnourished children.
• Ridge preservation and augmentation using regenerative materials to enhance implant predictability and esthetics.
• Sleep, physiology and disorders.
• Spatially discordant voltage alternans cause wavebreaks in ventricular fibrillation.
• Studies on the mechanism of action of sulfanilamide on mycelial felts of Rhizoctonia solani.
• Thyroid disorders and autoantibodies in systemic lupus erythematosus and rheumatoid arthritis patients.
• Using genomic microarrays to study insertional/transposon mutant libraries.
• [Aquired immune hemolytic anemias]