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Autonomic activity during desflurane anesthesia in patients with brain tumors.

Autonomic activity during desflurane anesthesia in patients with brain tumors. Research Abstract Details 

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  • Autonomic activity during desflurane anesthesia in patients with brain tumors. Abstract Text:

    chanannait paisansathanChanannait Paisansathan,william e hoffmanWilliam E Hoffman,michael leeMichael Lee,ranga c anandaRanga C Ananda,peggy wheelerPeggy Wheeler,chanannait paisansathanChanannait Paisansathan,william e hoffmanWilliam E Hoffman,michael leeMichael Lee,ranga c anandaRanga C Ananda,peggy wheelerPeggy Wheeler,

    OBJECTIVE: Although intracranial tumors may affect autonomic function, there are few reports of autonomic changes during anesthesia. The purpose of this study was to evaluate autonomic effects of anesthesia in patients with brain tumors compared to neurosurgical controls. METHODS: Two groups were evaluated: group 1 = 10 neurosurgical patients undergoing spinal cord surgery, group 2 = 10 patients with intracranial tumors. After placement of electrocardiogram and Response Entropy electroencephalogram (EEG) electrodes, 10 min baseline measures were made. Heart periods were transformed into a percentage index and heart rate entropy determined as a measure of variance of autonomic activity. Tone was evaluated as the balance between accelerator and inhibitory activity. Tone-entropy was measured during propofol anesthetic induction and the first 60 min of desflurane anesthesia before the start of surgery. RESULTS: Blood pressure and heart rate were similar between the groups. Starting at awake levels, vagal heart tone was observed. Anesthesia decreased vagal dominance to near zero in both groups. Heart rate entropy and EEG activity decreased during anesthesia with no significant difference between the groups. Desflurane concentrations required to maintain anesthesia were significantly lower in patients in brain tumors. CONCLUSION: Tone-entropy analysis of heart rate indicates anesthetic related depression of autonomic activity with no difference between groups. Normal titration of desflurane concentrations to maintain adequate blood pressure produced desflurane requirements that were lower in patients with brain tumors, while autonomic and EEG activity were similar.

    Autonomic activity during desflurane anesthesia in patients with brain tumors. Publishing Authors By Initials

    c paisansathanC Paisansathan,we hoffmanWE Hoffman,m leeM Lee,rc anandaRC Ananda,p wheelerP Wheeler,c paisansathanC Paisansathan,we hoffmanWE Hoffman,m leeM Lee,rc anandaRC Ananda,p wheelerP Wheeler,

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    Autonomic activity during desflurane anesthesia in patients with brain tumors. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Journal of clinical monitoring and computing

    VOLUME: 21

    Page Numbers: 265-9

    Journal Abbreviation:

    ISSN: 1387-1307

    DAY: 20

    MONTH: 07

    YEAR: 2007

    Autonomic activity during desflurane anesthesia in patients with brain tumors. Information

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    LANGUAGE: eng

    NlmUniqueID: 9806357

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    Grant and Affiliation Information for Autonomic activity during desflurane anesthesia in patients with brain tumors.

    AFFILIATION: Department of Anesthesiology, University of Illinois at Chicago, 1740 W Taylor, Suite 3200, Chicago, IL 60612, USA. oon@uic.edu

    Country: Netherlands

    Netherlands Research PublicationNetherlands Research Publication

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    MEDLINETA: J Clin Monit Comput

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