Autologous stem cell transplantation for patients with active Hodgkin's lymphoma: long-term outcome of 61 patients from a single institution.

Autologous stem cell transplantation for patients with active Hodgkin's lymphoma: long-term outcome of 61 patients from a single institution. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Autologous stem cell transplantation for patients with active Hodgkin's lymphoma: long-term outcome of 61 patients from a single institution. Abstract Text:

Carmen ,Olga Salamero,Leonor Arenillas,Juan Duque,Armando ,Montserrat Rovira,Alvaro ,Francesc ,Enric Carreras,Emili Montserrat,Carmen ,Olga Salamero,Leonor Arenillas,Juan Duque,Armando ,Montserrat Rovira,Alvaro ,Francesc ,Enric Carreras,Emili Montserrat,Carmen ,Olga Salamero,Leonor Arenillas,Juan Duque,Armando ,Montserrat Rovira,Alvaro ,Francesc ,Enric Carreras,Emili Montserrat,

Sixty-one patients with refractory or relapsed Hodgkin's lymphoma (HL) underwent high-dose chemotherapy and autologous stem cell transplantation (ASCT). All patients had active HL at the time of ASCT: 13 patients had partial remission, 14 refractory disease, 18 sensitive relapse, 4 resistant relapse, and 12 nontreated relapse. Overall transplant-related mortality (TRM) was 16.4% at 1 year. Twenty-eight patients (46%) achieved complete remission (CR). Actuarial 5-year overall survival (OS) and progression-free survival (PFS) were 51% and 47%, respectively. Patients with positive gallium-67 scintigraphy at 3 - 6 months after transplantation had a worse PFS at 5 years (28%) than those with negative 67Ga scan (80%) (p = 0.016), whereas no statistical differences were observed between patients with residual mass and those in CR according to computed tomography scan. In multivariate analysis, bulky disease at diagnosis, bone marrow stem cells, and stage IV at transplant were the only adverse prognostic factors significantly influencing OS. Bulky disease at diagnosis and stage IV at transplant adversely influenced PFS. Although long-term outcome of patients with active HL at the time of ASCT is poor due to a high TRM and a low CR after transplantation, a subgroup of patients with no adverse prognostic factors at ASCT gain benefit from this treatment.

Autologous stem cell transplantation for patients with active Hodgkin's lymphoma: long-term outcome of 61 patients from a single institution. Publishing Authors By Initials

C ,O Salamero,L Arenillas,J Duque,A ,M Rovira,A ,F ,E Carreras,E Montserrat,C ,O Salamero,L Arenillas,J Duque,A ,M Rovira,A ,F ,E Carreras,E Montserrat,C ,O Salamero,L Arenillas,J Duque,A ,M Rovira,A ,F ,E Carreras,E Montserrat,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Autologous stem cell transplantation for patients with active Hodgkin's lymphoma: long-term outcome of 61 patients from a single institution. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Leukemia & lymphoma

VOLUME: 48

Page Numbers: 1968-75

Journal Abbreviation: Leuk. Lymphoma

ISSN: 1042-8194

DAY: 5

MONTH: Oct

YEAR: 2007

Autologous stem cell transplantation for patients with active Hodgkin's lymphoma: long-term outcome of 61 patients from a single institution. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9007422

Autologous stem cell transplantation for patients with active Hodgkin's lymphoma: long-term outcome of 61 patients from a single institution. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Autologous stem cell transplantation for patients with active Hodgkin's lymphoma: long-term outcome of 61 patients from a single institution. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Autologous stem cell transplantation for patients with active Hodgkin's lymphoma: long-term outcome of 61 patients from a single institution.

AFFILIATION: Department of Hematology, Institute of Hematology and Oncology, Institut d'Investigacions Biomèdiques August Pi I Sunyer IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona, Spain. cmarti@clinic.ub.es

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Leuk Lymphoma

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Autologous stem cell transplantation for patients with active Hodgkin's lymphoma: long-term outcome of 61 patients from a single institution Related Publications

• Anemia associated with impaired erythropoietin secretion after allogeneic stem cell transplantation: incidence, risk factors, and response to treatment.
• Autologous stem cell transplantation for patients with active Hodgkin's lymphoma: long-term outcome of 61 patients from a single institution.
• Central nervous system involvement in mantle cell lymphoma.
• Chronic lymphocytic leukemia: case-based session.
• Clinical implications of ZAP-70 expressionin chronic lymphocytic leukemia.
• Fludarabine, cyclophosphamide, and mitoxantrone as initial therapy of chronic lymphocytic leukemia: high response rate and disease eradication.
• Further progress in CLL therapy.
• Kinetics of recovery of dendritic cell subsets after reduced-intensity conditioning allogeneic stem cell transplantation and clinical outcome.
• Management of sleep apnea: concordance between nonreference and reference centers.
• New prognostic markers in CLL.
• New prognostic markers in chronic lymphocytic leukemia.
• Potential dermal exposure to deltamethrin and risk assessment for manual sprayers: Influence of crop type.
• [Autologous haematopoietic stem cell transplantation in POEMS syndrome: results in 4 cases.]
• [Clinical forms of the sympathetic temporomandibular syndrome of Costen-Abelló.]
• [Not Available.]
• [Not Available.]