Autoimmunity versus tolerance: can dying cells tip the balance?

Autoimmunity versus tolerance: can dying cells tip the balance? Research Abstract Details 

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Autoimmunity versus tolerance: can dying cells tip the balance? Abstract Text:

Irene C B Viorritto,Nikolay P Nikolov,Richard M Siegel,

Apoptosis is a physiological process of self-destruction for cells that are damaged or programmed to die. Apoptosis occurs through a series of regulated events that allow cellular debris to be contained and efficiently phagocytosed without initiating a proinflammatory immune response. Recent data have linked physiological apoptosis and the uptake of apoptotic cells by macrophages and some subsets of dendritic cells to the maintenance of peripheral immune tolerance. However, when cells die through necrosis, spilling their intracellular contents, or are infected with various pathogens, activation of antigen-presenting cells and induction of an immune response can occur. Receptors for extrinsic pathogen-associated structures, such as membrane bound Toll-like receptors (TLRs) or intracellular Nod-like receptors (NLRs) can also respond to cross-reactive host molecules from dying cells and may focus autoimmune responses onto these antigens. Several autoimmune disorders have been linked to defects in the apoptotic process. Defective apoptosis of immune cells leads to autoimmunity, as in autoimmune lymphoproliferative syndrome (ALPS) associated with mutations in the death receptor Fas. Defective clearance of apoptotic cell debris can also lead to autoantibody production. We will discuss how cell death and apoptotic cell clearance may affect the finely tuned balance between peripheral immune tolerance and autoimmunity.

Autoimmunity versus tolerance: can dying cells tip the balance? Publishing Authors By Initials

IC Viorritto,NP Nikolov,RM Siegel,

For similar biological phenomena, cell phenomena, and immunity: immunity: immune tolerance research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: immune tolerance research

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Autoimmunity versus tolerance: can dying cells tip the balance? Journal Published:

PUBLICATION TYPE: Review

Journal: Clinical immunology (Orlando, Fla.)

VOLUME: 122

Page Numbers: 125-34

Journal Abbreviation: Clin. Immunol.

ISSN: 1521-6616

DAY: 5

MONTH: 10

YEAR: 2006

Autoimmunity versus tolerance: can dying cells tip the balance? Information

Number of References: 69

LANGUAGE: eng

NlmUniqueID: 100883537

Autoimmunity versus tolerance: can dying cells tip the balance? Keywords Mesh Terms:

KEYWORDS: Immune Tolerance

MESH TERMS: pathology

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Grant and Affiliation Information for Autoimmunity versus tolerance: can dying cells tip the balance?

AFFILIATION: Cell Signaling Section, Genetic Disease Research Branch NHGRI, NIH, Bethesda, MD 20892, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: Z01 AR041133-04

ACRONYM: AR

MEDLINETA: Clin Immunol

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