Autoantibodies to the proteasome in monosymptomatic optic neuritis may predict progression to multiple sclerosis.

Autoantibodies to the proteasome in monosymptomatic optic neuritis may predict progression to multiple sclerosis. Research Abstract Details 

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Autoantibodies to the proteasome in monosymptomatic optic neuritis may predict progression to multiple sclerosis. Abstract Text:

N H Beyer,J Milthers,A-M Bonde Lauridsen,G Houen,J Lautrup Frederiksen,N H Beyer,J Milthers,A-M Bonde Lauridsen,G Houen,J Lautrup Frederiksen,

OBJECTIVE: Proteasome autoantibodies (PAB) have been found in multiple sclerosis (MS) patient sera and cerebrospinal fluid (CSF). Presence of PAB could thus be a possible diagnostic marker for MS. We investigated whether PAB serum status in acute monosymptomatic optic neuritis (ON) and MS differed significantly from that of healthy controls, and whether or not PAB status is predictive of later MS development in patients with ON. MATERIAL AND METHODS: Sera from ON patients, MS patients and healthy donors were analysed retrospectively using ELISA. Subsequently, a small group of PAB-positive samples were subjected to SDS-PAGE, immunoblotting and 2-D PAGE. RESULTS: We found that 20 % (6/30) ON patients, 47 % (22/47) MS patients and 9 % (7/81) controls tested PAB positive using ELISA analysis. High PAB levels were found in 2 (4 %) MS patients, 1 (3 %) ON patient and 2 (3 %) controls. PAB positivity in ELISA was confirmed by immunoblotting. Separation of proteasome subunits by 2D PAGE followed by immunoblotting revealed no particular PAB subunit preference. CONCLUSIONS: A retrospective search in available patient files revealed that 6 of 6 (100.0 %) PAB-positive ON patients developed MS over time. Eight of 24 (33 %) PAB-negative ON patients developed MS over time and 47 % (14/30) of all ON patients developed MS. A series of patient CSF was analysed by ELISA to assess the possible correlation between PAB status of concurrent serum and CSF samples, but no correlation was found. However, the results from the six PAB-positive ON patients could potentially be of prognostic value.

Autoantibodies to the proteasome in monosymptomatic optic neuritis may predict progression to multiple sclerosis. Publishing Authors By Initials

NH Beyer,J Milthers,AM Lauridsen,G Houen,JL Frederiksen,NH Beyer,J Milthers,AM Bonde Lauridsen,G Houen,J Lautrup Frederiksen,

For similar proteins: protein subunits research abstracts see: proteins: protein subunits research

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Autoantibodies to the proteasome in monosymptomatic optic neuritis may predict progression to multiple sclerosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Scandinavian journal of clinical and laboratory in

VOLUME: 67

Page Numbers: 696-706

Journal Abbreviation: Scand. J. Clin. Lab. Invest.

ISSN: 0036-5513

DAY: 24

MONTH: 01

YEAR: 2007

Autoantibodies to the proteasome in monosymptomatic optic neuritis may predict progression to multiple sclerosis. Information

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LANGUAGE: eng

NlmUniqueID: 404375

Autoantibodies to the proteasome in monosymptomatic optic neuritis may predict progression to multiple sclerosis. Keywords Mesh Terms:

KEYWORDS: Protein Subunits

MESH TERMS: immunology

Chemical & Substance for Abstract: Autoantibodies to the proteasome in monosymptomatic optic neuritis may predict progression to multiple sclerosis. Information

Substance Name: Proteasome Endopeptidase Complex

Registry Number: EC 3.4.25.1

Grant and Affiliation Information for Autoantibodies to the proteasome in monosymptomatic optic neuritis may predict progression to multiple sclerosis.

AFFILIATION: Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark.

Country: Norway

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MEDLINETA: Scand J Clin Lab Invest

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