Autoantibodies to RNA helicase A: a new serologic marker of early lupus.

Autoantibodies to RNA helicase A: a new serologic marker of early lupus. Research Abstract Details 

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Autoantibodies to RNA helicase A: a new serologic marker of early lupus. Abstract Text:

Yoshioki Yamasaki,Sonali Narain,Hideo Yoshida,Liza Hernandez,Tolga Barker,Paulette C Hahn,Eric S Sobel,Mark S Segal,Hanno B Richards,Edward K L Chan,Westley H Reeves,Minoru Satoh,

OBJECTIVE: To investigate the clinical and immunologic significance of autoantibodies to RNA helicase A (RHA) in patients with systemic rheumatic diseases. METHODS: The study group comprised 1,119 individuals enrolled in the University of Florida Center for Autoimmune Diseases registry from 2000 to 2005. Diagnoses were based on standard criteria. Autoantibodies were analyzed by immunoprecipitation and Western blot assays. RESULTS: Anti-RHA was observed in 17 (6.2%) of 276 patients with systemic lupus erythematosus (SLE), 2 patients with antiphospholipid antibodies, and 3 other patients, but anti-RHA was not observed in any patient with polymyositis/dermatomyositis, systemic sclerosis, rheumatoid arthritis, or Sjögren's syndrome. Anti-RHA was present in only 2.9% of African American patients, compared with 6.0% of white patients and 12-25% of patients of other races; this was in striking contrast to the frequency of anti-Sm in African American patients (27.2%). Among patients with SLE, anti-RHA was common in young patients (26% of those whose initial visit was at an age younger than 20 years versus 3-4% of those who were initially seen at ages 20-49 years) and at an early stage of disease (23% of those whose first clinic visit was within 1 year of disease onset versus 2-8% of those whose first visit was at least 1 year after disease onset). In 9 of 11 patients, levels of anti-RHA decreased to <10% of the initial value within 9-37 months, while levels of coexisting anti-Ro or anti-Su remained the same. New specificities developed in 2 patients (anti-nuclear RNP and anti-Sm, and anti-ribosomal P, respectively). These data suggest that the level of anti-RHA diminishes over time, and that anti-RHA is regulated via a mechanism different from that for other lupus-related autoantibodies. CONCLUSION: Anti-RHA is a new serologic marker for SLE. It is produced mainly in young non-African Americans at an early stage of their disease. Anti-RHA has a unique tendency to diminish over time. The production of anti-RHA may depend on a process restricted to early SLE, or it may be highly sensitive to treatment.

Autoantibodies to RNA helicase A: a new serologic marker of early lupus. Publishing Authors By Initials

Y Yamasaki,S Narain,H Yoshida,L Hernandez,T Barker,PC Hahn,ES Sobel,MS Segal,HB Richards,EK Chan,WH Reeves,M Satoh,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Autoantibodies to RNA helicase A: a new serologic marker of early lupus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Arthritis and rheumatism

VOLUME: 56

Page Numbers: 596-604

Journal Abbreviation: Arthritis Rheum.

ISSN: 0004-3591

DAY: 3

MONTH: Feb

YEAR: 2007

Autoantibodies to RNA helicase A: a new serologic marker of early lupus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370605

Autoantibodies to RNA helicase A: a new serologic marker of early lupus. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: immunology

Chemical & Substance for Abstract: Autoantibodies to RNA helicase A: a new serologic marker of early lupus. Information

Substance Name: DHX9 protein, human

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for Autoantibodies to RNA helicase A: a new serologic marker of early lupus.

AFFILIATION: University of Florida, Gainesville, FL 32610, USA.

Country: United States

AGENCY: United States NCRR

GRANT: M01-RR-00082

ACRONYM: RR

MEDLINETA: Arthritis Rheum

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