Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons.

Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons. Research Abstract Details 

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Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons. Abstract Text:

Mainak Das,Swanand Patil,Neelima Bhargava,Jung-Fong Kang,Lisa M Riedel,Sudipta Seal,James J Hickman,

This paper describes the evaluation of the auto-catalytic anti-oxidant behavior and biocompatibility of cerium oxide nanoparticles for applications in spinal cord repair and other diseases of the central nervous system. The application of a single dose of nano-ceria at a nano-molar concentration is biocompatible, regenerative and provides a significant neuroprotective effect on adult rat spinal cord neurons. Retention of neuronal function is demonstrated from electrophysiological recordings and the possibility of its application to prevent ischemic insult is suggested from an oxidative injury assay. A mechanism is proposed to explain the auto-catalytic properties of these nanoparticles.

Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons. Publishing Authors By Initials

M Das,S Patil,N Bhargava,JF Kang,LM Riedel,S Seal,JJ Hickman,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biomaterials

VOLUME: 28

Page Numbers: 1918-25

Journal Abbreviation: Biomaterials

ISSN: 0142-9612

DAY: 12

MONTH: 01

YEAR: 2007

Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons. Information

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LANGUAGE: eng

NlmUniqueID: 8100316

Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: chemistry

Chemical & Substance for Abstract: Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons. Information

Substance Name: Cerium

Registry Number: 7440-45-1

Grant and Affiliation Information for Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons.

AFFILIATION: NanoScience Technology Center, 12424 Research Parkway, Suite 400, University of Central Florida, Orlando, FL 32826, USA.

Country: England

AGENCY: United States NINDS

GRANT: R01 NS050452-01A1

ACRONYM: NS

MEDLINETA: Biomaterials

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