Autistic traits in a population-based ADHD twin sample.

Autistic traits in a population-based ADHD twin sample. Research Abstract Details 

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Autistic traits in a population-based ADHD twin sample. Abstract Text:

Angela M Reiersen,John N Constantino,Heather E Volk,Richard D Todd,

BACKGROUND: Most diagnostic nomenclatures do not allow for the concurrent diagnosis of autism and attention-deficit/hyperactivity disorder (ADHD). Clinic-based studies suggest autistic symptoms are common in children with ADHD, but such studies are prone to referral bias. This study assesses whether children with ADHD selected from the general twin population have elevated levels of autistic traits. METHODS: Nine hundred forty-six twins identified by Missouri birth records were assigned to DSM-IV ADHD diagnoses and seven population-derived ADHD subtypes defined through latent class analysis of DSM-IV ADHD symptoms. The Social Responsiveness Scale (SRS) was used as a quantitative measure of autistic traits. Linear regression was used to evaluate whether mean SRS scores differed between ADHD diagnostic groups. RESULTS: Mean SRS scores for DSM-IV predominantly inattentive subtype and combined subtype ADHD groups were significantly higher than for subjects without DSM-IV ADHD (p < .001, both comparisons). Five of the population-derived ADHD subtypes (talkative-impulsive, mild and severe inattentive, mild and severe combined) had significantly higher mean SRS scores compared to the latent class subtype with few ADHD symptoms (p < .001, all comparisons). DSM-IV combined subtype and the population-derived severe combined subtype had the highest mean total SRS scores and the highest mean scores for each of the three autism symptom domains, with a substantial proportion of individuals scoring in the clinically significant range. CONCLUSIONS: This study provides population-based evidence for clinically significant elevations of autistic traits in children meeting diagnostic criteria for ADHD. These results have implications for the design and interpretation of studies of both disorders.

Autistic traits in a population-based ADHD twin sample. Publishing Authors By Initials

AM Reiersen,JN Constantino,HE Volk,RD Todd,

For similar reproductive and urinary physiology: reproduction: pregnancy: pregnancy, multiple: twins research abstracts see: reproductive and urinary physiology: reproduction: pregnancy: pregnancy, multiple: twins research

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Autistic traits in a population-based ADHD twin sample. Journal Published:

PUBLICATION TYPE: Twin Study

Journal: Journal of child psychology and psychiatry, and al

VOLUME: 48

Page Numbers: 464-72

Journal Abbreviation:

ISSN: 0021-9630

DAY: 3

MONTH: May

YEAR: 2007

Autistic traits in a population-based ADHD twin sample. Information

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LANGUAGE: eng

NlmUniqueID: 375361

Autistic traits in a population-based ADHD twin sample. Keywords Mesh Terms:

KEYWORDS: Twins

MESH TERMS: diagnosis

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Grant and Affiliation Information for Autistic traits in a population-based ADHD twin sample.

AFFILIATION: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110-1093, USA. reiersea@psychiatry.wustl.edu

Country: England

AGENCY: United States NIMH

GRANT: MH74272

ACRONYM: MH

MEDLINETA: J Child Psychol Psychiatry

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