Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells.

Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Research Abstract Details 

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Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Abstract Text:

Zhong Guan,Xian-ren Wang,Xiao-feng Zhu,Xue-fei Huang,Jie Xu,Li-hui Wang,Xiang-bo Wan,Zi-jie Long,Jian-nan Liu,Gong-kan Feng,Wenlin Huang,Yi-xin Zeng,Fu-jin Chen,Quentin Liu,

Centrosomal Aurora-A (Aur-A) kinase ensures proper spindle assembly and accurate chromosome segregation in mitosis. Overexpression of Aur-A leads to centrosome amplification, aberrant spindle, and consequent genetic instability. In the present study, Aur-A was found to be overexpressed in laryngeal squamous cell carcinoma (LSCC). Moreover, Aur-A expression was adversely correlated with median survival, and further identified as a potential independent factor for disease prognosis. Suppression of Aurora kinase activity chemically or genetically led to LSCC Hep2 cell cycle arrest and apoptotic cell death. Importantly, we found that Aur-A increases cell migration and this novel function was correlated with Akt1 activation. The enhanced cell migration induced by Aur-A overexpression could be abrogated by either small-molecule Akt1 inhibitor or short interfering RNA. VX-680, a selective Aurora kinase inhibitor, decreased Akt1 phosphorylation at Ser(473) and inhibited cell migration, but failed to do so in constitutive active Akt1 (myr-Akt1)-overexpressed cells. Moreover, our data suggested that overexpression of Aur-A kinase might also contribute to radioresistance of LSCC. Inhibiting Aur-A by VX-680 induced expression of p53 and potently sensitized cells to radiotherapy, leading to significant cell death. Ectopic overexpression of Aur-A, however, reduced p53 level and rendered cells more resistant to irradiation. Taken together, we showed that Aur-A kinase, a negative prognostic marker, promotes migration and reduces radiosensitivity in laryngeal cancer cells.

Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Publishing Authors By Initials

Z Guan,XR Wang,XF Zhu,XF Huang,J Xu,LH Wang,XB Wan,ZJ Long,JN Liu,GK Feng,W Huang,YX Zeng,FJ Chen,Q Liu,

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Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer research

VOLUME: 67

Page Numbers: 10436-44

Journal Abbreviation: Cancer Res.

ISSN: 1538-7445

DAY: 1

MONTH: Nov

YEAR: 2007

Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Information

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LANGUAGE: eng

NlmUniqueID: 2984705

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Grant and Affiliation Information for Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells.

AFFILIATION: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.

Country: United States

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MEDLINETA: Cancer Res

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