Augmentation of the gastric mucosal defense mechanism induced by KW-5805, a novel antiulcer agent.

Augmentation of the gastric mucosal defense mechanism induced by KW-5805, a novel antiulcer agent. Research Abstract Details 

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Augmentation of the gastric mucosal defense mechanism induced by KW-5805, a novel antiulcer agent. Abstract Text:

H Tanaka,N Kosaka,A Tomaru,K Shuto,T Ogihara,N Sato,

KW-5805 (a new antiulcer agent), given p. o. at 30 mg/kg to rats, significantly increased the amount of gastric adherent mucus and mucosal glycoproteins. Gastric mucosal glucosamine synthetase activity was significantly enhanced by KW-5805 (30 mg/kg, p. o.). KW-5805 (10, 30 mg/kg, p. o.) significantly suppressed the decrease of gastric mucosal blood volume and oxygen sufficiency induced by hemorrhagic shock. The agent also significantly inhibited the extravasation of Evans blue into the gastric mucosa after ischemia-reinfusion. In conclusion, KW-5805 increased biosynthesis, storage and secretion of gastric mucus and improved the gastric mucosal hemodynamics.

Augmentation of the gastric mucosal defense mechanism induced by KW-5805, a novel antiulcer agent. Publishing Authors By Initials

H Tanaka,N Kosaka,A Tomaru,K Shuto,T Ogihara,N Sato,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: blood circulation: regional blood flow research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: blood circulation: regional blood flow research

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Augmentation of the gastric mucosal defense mechanism induced by KW-5805, a novel antiulcer agent. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME: 162

Page Numbers: 170-3

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 1989

Augmentation of the gastric mucosal defense mechanism induced by KW-5805, a novel antiulcer agent. Information

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LANGUAGE: eng

NlmUniqueID: 437034

Augmentation of the gastric mucosal defense mechanism induced by KW-5805, a novel antiulcer agent. Keywords Mesh Terms:

KEYWORDS: Regional Blood Flow

MESH TERMS: drug effects

Chemical & Substance for Abstract: Augmentation of the gastric mucosal defense mechanism induced by KW-5805, a novel antiulcer agent. Information

Substance Name: Glutamine-Fructose-6-Phosphate Transamin

Registry Number: EC 2.6.1.16

Grant and Affiliation Information for Augmentation of the gastric mucosal defense mechanism induced by KW-5805, a novel antiulcer agent.

AFFILIATION: Pharm. Res. Lab., Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.

Country: NORWAY

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MEDLINETA: Scand J Gastroenterol Suppl

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