Attenuation of beta-amyloid-induced toxicity by sialic-acid-conjugated dendrimers: role of sialic acid attachment.

Attenuation of beta-amyloid-induced toxicity by sialic-acid-conjugated dendrimers: role of sialic acid attachment. Research Abstract Details 

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Attenuation of beta-amyloid-induced toxicity by sialic-acid-conjugated dendrimers: role of sialic acid attachment. Abstract Text:

Dhara A Patel,James E Henry,Theresa A Good,

beta-Amyloid (Abeta) is the primary protein component of senile plaques in Alzheimer's disease and is believed to be associated with neurotoxicity in the disease. We and others have shown that Abeta binds with relatively high affinity to clustered sialic acid residues on cell surfaces and that removal of cell surface sialic acids attenuates Abeta toxicity. We have also shown that sialic acid functionalized dendrimeric polymers can act as mimics of cell surface sialic acid clusters and attenuate Abeta-induced neurotoxicity. In the current study, we prepared sialic-acid-conjugated dendrimers using a physiologically relevant attachment of the sialic acid to the dendrimeric termini, and evaluated the Abeta toxicity attenuation properties of the dendrimers. We compared performance of sialic-acid-conjugated dendrimeric polymers in which the sialic acid moieties were attached to dendrimeric termini via the anomeric hydroxyl group of the sialic acid, a physiological attachment, to polymers in which the attachment was made via the carboxylic acid group on the sialic acid, a non-physiological attachment. This work enhances our understanding of Abeta-cell surface binding and is a step towards the development of new classes of sequestering agents as therapeutics for the prevention of Abeta toxicity in AD.

Attenuation of beta-amyloid-induced toxicity by sialic-acid-conjugated dendrimers: role of sialic acid attachment. Publishing Authors By Initials

DA Patel,JE Henry,TA Good,

For similar peptides: peptide fragments research abstracts see: peptides: peptide fragments research

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Attenuation of beta-amyloid-induced toxicity by sialic-acid-conjugated dendrimers: role of sialic acid attachment. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Brain research

VOLUME: 1161

Page Numbers: 95-105

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 9

MONTH: 06

YEAR: 2007

Attenuation of beta-amyloid-induced toxicity by sialic-acid-conjugated dendrimers: role of sialic acid attachment. Information

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LANGUAGE: eng

NlmUniqueID: 45503

Attenuation of beta-amyloid-induced toxicity by sialic-acid-conjugated dendrimers: role of sialic acid attachment. Keywords Mesh Terms:

KEYWORDS: Peptide Fragments

MESH TERMS: toxicity

Chemical & Substance for Abstract: Attenuation of beta-amyloid-induced toxicity by sialic-acid-conjugated dendrimers: role of sialic acid attachment. Information

Substance Name: Nerve Growth Factor

Registry Number: 9061-61-4

Grant and Affiliation Information for Attenuation of beta-amyloid-induced toxicity by sialic-acid-conjugated dendrimers: role of sialic acid attachment.

AFFILIATION: Department of Chemical and Biochemical Engineering, University of Maryland Baltimore County (UMBC), Baltimore, MD 21250, USA.

Country: Netherlands

AGENCY: United States NINDS

GRANT: NS050346

ACRONYM: NS

MEDLINETA: Brain Res

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