Atrial natriuretic peptide and the natriuresis due to acute beta-blockade in conscious hypertensive rats.

Atrial natriuretic peptide and the natriuresis due to acute beta-blockade in conscious hypertensive rats. Research Abstract Details 

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Atrial natriuretic peptide and the natriuresis due to acute beta-blockade in conscious hypertensive rats. Abstract Text:

K Pettersson,J Anderson,M Sjölander,S R Bloom,

Acute beta-adrenoceptor blockade in rats is known to produce a natriuresis of hitherto uncertain cause. To investigate this phenomenon plasma atrial natriuretic peptide (ANP) concentrations were measured in groups of conscious metoprolol-treated and control rats. In the active treatment group the blood pressure decreased slowly, as expected, settling at a lower level after 2 hours, and the mean sodium excretion doubled 1 hour after metoprolol administration. This natriuretic effect was maximal after 40-60 minutes and thereafter slowly declined towards basal values. The period of enhanced sodium excretion was associated with a significant rise (68%) of the mean ANP plasma concentration. It suggested that this increase in plasma ANP concentration can mediate the acute natriuretic effect beta-adrenoceptor blockade.

Atrial natriuretic peptide and the natriuresis due to acute beta-blockade in conscious hypertensive rats. Publishing Authors By Initials

K Pettersson,J Anderson,M Sjölander,SR Bloom,

For similar inorganic chemicals: elements: metals, alkali: sodium research abstracts see: inorganic chemicals: elements: metals, alkali: sodium research

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Atrial natriuretic peptide and the natriuresis due to acute beta-blockade in conscious hypertensive rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 9

Page Numbers: 95-107

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1987

Atrial natriuretic peptide and the natriuresis due to acute beta-blockade in conscious hypertensive rats. Information

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LANGUAGE: eng

NlmUniqueID: 8207790

Atrial natriuretic peptide and the natriuresis due to acute beta-blockade in conscious hypertensive rats. Keywords Mesh Terms:

KEYWORDS: Sodium

MESH TERMS: urine

Chemical & Substance for Abstract: Atrial natriuretic peptide and the natriuresis due to acute beta-blockade in conscious hypertensive rats. Information

Substance Name: Atrial Natriuretic Factor

Registry Number: 85637-73-6

Grant and Affiliation Information for Atrial natriuretic peptide and the natriuresis due to acute beta-blockade in conscious hypertensive rats.

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Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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