ATR and ATRIP: partners in checkpoint signaling.

ATR and ATRIP: partners in checkpoint signaling. Research Abstract Details 

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ATR and ATRIP: partners in checkpoint signaling. Abstract Text:

D Cortez,S Guntuku,J Qin,S J Elledge,

The checkpoint kinases ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3 related) transduce genomic stress signals to halt cell cycle progression and promote DNA repair. We report the identification of an ATR-interacting protein (ATRIP) that is phosphorylated by ATR, regulates ATR expression, and is an essential component of the DNA damage checkpoint pathway. ATR and ATRIP both localize to intranuclear foci after DNA damage or inhibition of replication. Deletion of ATR mediated by the Cre recombinase caused the loss of ATR and ATRIP expression, loss of DNA damage checkpoint responses, and cell death. Therefore, ATR is essential for the viability of human somatic cells. Small interfering RNA directed against ATRIP caused the loss of both ATRIP and ATR expression and the loss of checkpoint responses to DNA damage. Thus, ATRIP and ATR are mutually dependent partners in cell cycle checkpoint signaling pathways.

ATR and ATRIP: partners in checkpoint signaling. Publishing Authors By Initials

D Cortez,S Guntuku,J Qin,SJ Elledge,

For similar proteins: viral proteins research abstracts see: proteins: viral proteins research

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ATR and ATRIP: partners in checkpoint signaling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Science (New York, N.Y.)

VOLUME: 294

Page Numbers: 1713-6

Journal Abbreviation: Science

ISSN: 0036-8075

DAY: 23

MONTH: Nov

YEAR: 2001

ATR and ATRIP: partners in checkpoint signaling. Information

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LANGUAGE: eng

NlmUniqueID: 404511

ATR and ATRIP: partners in checkpoint signaling. Keywords Mesh Terms:

KEYWORDS: Viral Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: ATR and ATRIP: partners in checkpoint signaling. Information

Substance Name: three prime repair exonuclease 1

Registry Number: EC 3.1.16.-

Grant and Affiliation Information for ATR and ATRIP: partners in checkpoint signaling.

AFFILIATION: Verna and Mars McLean Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

Country: United States

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MEDLINETA: Science

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