ATP depletion is the major cause of MPP(+) induced dopamine neuronal death and worm lethality in a-synuclein transgenic C. elegans.

ATP depletion is the major cause of MPP(+) induced dopamine neuronal death and worm lethality in a-synuclein transgenic C. elegans. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

ATP depletion is the major cause of MPP(+) induced dopamine neuronal death and worm lethality in a-synuclein transgenic C. elegans. Abstract Text:

Yi-Min Wang,Pu Pu,Wei-Dong LE,Yi-Min Wang,Pu Pu,Wei-Dong Le,

Objective To investigate the toxic effect of environmental neurotoxin MPP(+) to C. elegans and identify the mechanisms that cause the toxicity. Methods Human alpha-synuclein transgenic C. elegans was used as the animal model, the toxic effect of MPP(+) to dopamine (DA) neurons and the lifespan of worms was tested. The worms were feed with OP50 to determine whether ATP increase can rescue the worm from toxicity. ATP level and aberrant protein accumulation were analyzed in the MPP(+) treated worms with or without OP50 addition. Results We found that MPP(+) induced DA cell death and worm lethality, which could be prevented by OP50 treatment. OP50 exerted the protective effect by up-regulating ATP level, even though it also induced accumulation of alpha-synuclein. Despite the undefined role of protein aggregation to the cell death, our results showed that the toxicity of MPP(+) was mainly caused by the ATP depletion in the alpha-synuclein transgenic C. elegans. Conclusion MPP(+) could induce DA neuronal death and worm lethality in alpha-synuclein transgenic C. elegans; Compared with the aggregation of alpha-synuclein, the major cause of MPP(+) toxicity appeared due to ATP depletion.

ATP depletion is the major cause of MPP(+) induced dopamine neuronal death and worm lethality in a-synuclein transgenic C. elegans. Publishing Authors By Initials

YM Wang,P Pu,WD LE,YM Wang,P Pu,WD Le,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

ATP depletion is the major cause of MPP(+) induced dopamine neuronal death and worm lethality in a-synuclein transgenic C. elegans. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuroscience bulletin

VOLUME: 23

Page Numbers: 329-35

Journal Abbreviation:

ISSN: 1673-7067

DAY: 7

MONTH: Nov

YEAR: 2007

ATP depletion is the major cause of MPP(+) induced dopamine neuronal death and worm lethality in a-synuclein transgenic C. elegans. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101256850

ATP depletion is the major cause of MPP(+) induced dopamine neuronal death and worm lethality in a-synuclein transgenic C. elegans. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: ATP depletion is the major cause of MPP(+) induced dopamine neuronal death and worm lethality in a-synuclein transgenic C. elegans. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for ATP depletion is the major cause of MPP(+) induced dopamine neuronal death and worm lethality in a-synuclein transgenic C. elegans.

AFFILIATION: Neural genomics Laboratory, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; E-mail: wdle@sibs.ac.cn.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Neurosci Bull

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

ATP depletion is the major cause of MPP+ induced dopamine neuronal death and worm lethality in a-synuclein transgenic C elegans Related Publications

• ATP depletion is the major cause of MPP(+) induced dopamine neuronal death and worm lethality in a-synuclein transgenic C. elegans.
• Adequacy of benzo(a)pyrene and benzene soluble materials as indicators of exposure to polycyclic aromatic hydrocarbons in a söderberg aluminum smelter.
• Age-dependent effects of hedgehog protein on chondrocytes.
• Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin.
• Cardiovascular disease.
• Description of a new lung fluke species, Paragonimus vietnamensis sp. nov. (Trematoda, Paragonimidae), found in northern Vietnam.
• Dispensing opioid substitution treatment: practices, attitudes and intentions of community-based pharmacists.
• Green tea extract and (-)-epigallocatechin-3-gallate inhibit mast cell-stimulated type I collagen expression in keloid fibroblasts via blocking PI-3K/AkT signaling pathways.
• HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy.
• Identifying and targeting hypoxia in head and neck cancer: a brief overview of current approaches.
• Loss of BCL-XL in rod photoreceptors: Increased susceptibility to bright light stress.
• Nicotine induces hypoxia-inducible factor-1alpha expression in human lung cancer cells via nicotinic acetylcholine receptor-mediated signaling pathways.
• Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells.
• Plasma osteopontin is an independent prognostic marker for head and neck cancers.
• Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators.
• Quantification of motion of different thoracic locations using four-dimensional computed tomography: implications for radiotherapy planning.
• Spinal cord dopamine receptor expression and function in mice with 6-OHDA lesion of the A11 nucleus and dietary iron deprivation.
• Stem cell transplantation: a promising therapy for Parkinson's disease.
• Strategic plans to promote head and neck cancer translational research within the radiation therapy oncology group: a report from the translational research program.
• Study of interactions between arsenicals and thioredoxins (human and E. coli) using mass spectrometry.
• The CRF(1) receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats.
• The crying infant.
• Ultrasensitive assays for proteins.
• Visual impairment in leprosy patients in northern Viet Nam.
• [Degradation of endocrine disrupting chemicals(EDCs)-BP by combination of UV/ micro-aeration process and impact factors]
• [Effect of water quality on degradation of 17alpha-ethynyestradiol (EE2) by UV/H2O2 combination process]
• [Effects of organic pollutants in drinking water on the removal of dimethyl phthalate by advanced oxidation processes]
• [Impact of organic matter in water on the adsorption of EDCS (BPA) onto granular activated carbon (GAC) from the view of molecular weight distribution]
• [Revision of submucous resection of nasal septum]
• [Study on digital radiography equilibrium processing]